Trandate Side Effects
Generic name: labetalol
Medically reviewed by Drugs.com. Last updated on Mar 19, 2024.
Note: This document contains side effect information about labetalol. Some dosage forms listed on this page may not apply to the brand name Trandate.
Applies to labetalol: intravenous solution. Other dosage forms:
Serious side effects of Trandate
Along with its needed effects, labetalol (the active ingredient contained in Trandate) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking labetalol:
More common
- Dizziness
- tingling of the scalp or skin
Less common
- Black, tarry stools
- blurred vision
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- chills
- clay-colored stools
- confusion
- dark urine
- diarrhea
- dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
- fast, pounding, or irregular heartbeat or pulse
- feeling of constant movement of self or surroundings
- fever
- general tiredness and weakness
- headache
- itching skin
- light-colored stools
- loss of appetite
- nausea and vomiting
- palpitations
- sensation of spinning
- skin rash
- stomach pain
- sweating
- unpleasant breath odor
- unusual tiredness or weakness
- vomiting of blood
- yellow eyes or skin
Rare
- Chest pain, discomfort, or tightness
- cough
- difficulty swallowing
- hives or welts
- hoarseness
- irritation
- joint pain, stiffness, or swelling
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- lightheadedness, dizziness, or fainting
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- redness of skin
- slow heartbeat
- stomach pain
- swelling of the eyelids, face, lips, hands, or feet
- trouble breathing or swallowing
Get emergency help immediately if any of the following symptoms of overdose occur while taking labetalol:
Symptoms of overdose
- Dilated neck veins
- extreme fatigue
- irregular breathing
- loss of bladder control
- muscle spasm or jerking of all extremities
- noisy breathing
- seizures
- sudden loss of consciousness
- weight gain
Other side effects of Trandate
Some side effects of labetalol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Stuffy nose
Less common
- Acid or sour stomach
- belching
- change in taste or bad, unusual, or unpleasant (after) taste
- decreased interest in sexual intercourse
- heartburn
- inability to have or keep an erection
- increased yawning
- indigestion
- loss in sexual ability, desire, drive, or performance
- sleepiness or unusual drowsiness
- stomach discomfort or upset
- vomiting
For Healthcare Professionals
Applies to labetalol: compounding powder, intravenous solution, oral tablet.
Cardiovascular
Common (1% to 10%): Edema, postural hypotension
Frequency not reported: Bradycardia, heart block, heart failure, hypotension, ankle edema, increase of an existing intermittent claudication, postural hypotension, cold or cyanotic extremities, Raynaud's phenomenon, paresthesia of the extremities, syncope[Ref]
Dermatologic
Uncommon (0.1% to 1%): Increased sweating
Frequency not reported: Systemic lupus erythematosus, rashes (e.g., generalized maculopapular, lichenoid, urticarial, bullous lichen planus, psoriaform, facial erythema, Peyronie's disease, reversible alopecia)[Ref]
Endocrine
Frequency not reported: Masking of the normal response to hypoglycemia (sweating and tachycardia); this may be important in some patients with diabetes mellitus[Ref]
Gastrointestinal
Common (1% to 10%): Nausea, dyspepsia, vomiting
Uncommon (0.1% to 1%): Diarrhea
Frequency not reported: Epigastric pain[Ref]
Genitourinary
Common (1% to 10%): Ejaculation failure, impotence
Frequency not reported: Difficulty in micturition (including acute urinary bladder retention)[Ref]
Hepatic
Common (1% to 10%): Transient elevations of liver function tests
Frequency not reported: Hepatic necrosis, hepatitis, cholestatic jaundice[Ref]
Hypersensitivity
Rare (less than 0.1%): Hypersensitivity (e.g., rash, urticaria, pruritus, angioedema, dyspnea), anaphylactoid reactions[Ref]
Immunologic
Frequency not reported: Antimitochondrial antibodies[Ref]
Metabolic
Very rare (less than 0.01%): Hyperkalemia[Ref]
Musculoskeletal
Frequency not reported: Muscle cramps, toxic myopathy[Ref]
Nervous system
Very common (10% or more): Dizziness (11%)
Common (1% to 10%): Headache, taste distortion, vertigo, paresthesia, scalp tingling
Uncommon (0.1% to 1%): Drowsiness
Frequency not reported: Tremor[Ref]
Ocular
Common (1% to 10%): Vision abnormality
Frequency not reported: Dry eyes
Postmarketing reports: Intraoperative Floppy Iris Syndrome (IFIS) observed during cataract surgery[Ref]
Respiratory
Common (1% to 10%): Nasal stuffiness, dyspnea
Frequency not reported: Bronchospasm, interstitial lung disease[Ref]
Other
Common (1% to 10%): Fatigue, asthenia
Frequency not reported: Positive antinuclear factor[Ref]
Psychiatric
Frequency not reported: Depressed mood and lethargy, hallucinations, psychoses, confusion, sleep disturbances, nightmares[Ref]
More about Trandate (labetalol)
- Check interactions
- Compare alternatives
- Reviews (1)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Generic availability
- Drug class: non-cardioselective beta blockers
- Breastfeeding
Patient resources
- Trandate drug information
- Trandate (Labetalol Intravenous) (Advanced Reading)
- Trandate (Labetalol Oral) (Advanced Reading)
- Trandate (Labetalol Tablets)
Other brands
Professional resources
Related treatment guides
References
1. Cerner Multum, Inc. UK Summary of Product Characteristics.
2. Cerner Multum, Inc. Australian Product Information.
3. Product Information. Labetalol Hydrochloride (labetalol). Watson Pharmaceuticals. 2016.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.