Labetalol Dosage

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Usual Adult Dose for:

Usual Geriatric Dose for:

Additional dosage information:

Usual Adult Dose for Hypertension

Oral:
Initial dose: 100 mg orally twice a day whether used alone or added to a diuretic regimen.
Maintenance dose: 200 to 400 mg orally twice a day.

Parenteral:
Repeated IV Injection: Initial dose: 20 mg (0.25 mg/kg) by slow IV injection over a 2 minute period.
Additional injections of 40 to 80 mg can be given at 10 minute intervals until a desired supine blood pressure is achieved or a total of 300 mg of labetalol has been injected.
The maximum effect usually occurs within 5 minutes of each injection.
Slow continuous IV Infusion: Add 40 mL of labetalol Injection to 160 mL of a commonly used IV fluid such that the resultant 200 mL of solution contains 200 mg of labetalol, 1 mg/mL. The diluted solution should be administered at a rate of 2 mL/min to deliver 2 mg/min.
Alternatively, add 40 mL of labetalol Injection to 250 mL of a commonly used IV fluid. The resultant solution will contain 200 mg of labetalol, approximately 2 mg/3 mL. The diluted solution should be administered at a rate of 3 mL/min to deliver approximately 2 mg/min.

Usual Adult Dose for Hypertensive Emergency

Oral:
Initial dose: 100 mg orally twice a day whether used alone or added to a diuretic regimen.
Maintenance dose: 200 to 400 mg orally twice a day.

Parenteral:
Repeated IV Injection: Initial dose: 20 mg (0.25 mg/kg) by slow IV injection over a 2 minute period.
Additional injections of 40 to 80 mg can be given at 10 minute intervals until a desired supine blood pressure is achieved or a total of 300 mg of labetalol has been injected.
The maximum effect usually occurs within 5 minutes of each injection.
Slow continuous IV Infusion: Add 40 mL of labetalol Injection to 160 mL of a commonly used IV fluid such that the resultant 200 mL of solution contains 200 mg of labetalol, 1 mg/mL. The diluted solution should be administered at a rate of 2 mL/min to deliver 2 mg/min.
Alternatively, add 40 mL of labetalol Injection to 250 mL of a commonly used IV fluid. The resultant solution will contain 200 mg of labetalol, approximately 2 mg/3 mL. The diluted solution should be administered at a rate of 3 mL/min to deliver approximately 2 mg/min.

Usual Adult Dose for Pheochromocytoma

Oral:
Initial dose: 100 mg orally twice a day whether used alone or added to a diuretic regimen.
Maintenance dose: 200 to 400 mg orally twice a day.

Parenteral:
Repeated IV Injection: Initial dose: 20 mg (0.25 mg/kg) by slow IV injection over a 2 minute period.
Additional injections of 40 to 80 mg can be given at 10 minute intervals until a desired supine blood pressure is achieved or a total of 300 mg of labetalol has been injected.
The maximum effect usually occurs within 5 minutes of each injection.
Slow continuous IV Infusion: Add 40 mL of labetalol Injection to 160 mL of a commonly used IV fluid such that the resultant 200 mL of solution contains 200 mg of labetalol, 1 mg/mL. The diluted solution should be administered at a rate of 2 mL/min to deliver 2 mg/min.
Alternatively, add 40 mL of labetalol Injection to 250 mL of a commonly used IV fluid. The resultant solution will contain 200 mg of labetalol, approximately 2 mg/3 mL. The diluted solution should be administered at a rate of 3 mL/min to deliver approximately 2 mg/min.

Usual Geriatric Dose for Hypertension

Initial dose: 50 mg to 100 mg orally twice a day.
May be titrated upwards in increments of 50 mg to 100 mg twice daily as required for control of blood pressure.
Maintenance dose: 100 to 200 mg orally twice a day.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

Because labetalol is primarily metabolized by the liver, it may be prudent to initiate labetalol at dose of 50 mg orally twice a day in patients with liver disease.

Dose Adjustments

After 2 or 3 days, using standing blood pressure as an indicator, dosage may be titrated in increments of 100 mg twice daily every 2 to 3 days. Patients with severe hypertension may require from 1200 to 2400 mg/day, with or without thiazide diuretics. Should side effects (principally nausea or dizziness) occur with these doses administered twice daily, the same total daily dose administered three times daily may improve tolerability and facilitate further titration. Titration increments should not exceed 200 mg twice daily.

Dialysis

Labetalol is not removed by hemo- or peritoneal dialysis. A supplemental dose is not needed.

Other Comments

Compared with Caucasian patients, Black patients have a reduced blood pressure response to monotherapy with beta-blockers; however, the reduced response is largely eliminated if combination therapy that includes an adequate dose of a diuretic is instituted.

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