Thiabendazole Side Effects
Some side effects of thiabendazole may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to thiabendazole: oral suspension, oral tablet chewable
Along with its needed effects, thiabendazole may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking thiabendazole:More common
- diarrhea (severe)
- hallucinations (seeing, hearing, and feeling things that are not there)
- loss of appetite
- nausea and vomiting (severe)
- numbness or tingling in the hands or feet
- Skin rash or itching
Check with your doctor as soon as possible if any of the following side effects occur while taking thiabendazole:Rare
- Aching of joints and muscles
- blurred or yellow vision
- convulsions (seizures)
- dark urine
- lower back pain
- pain or burning while urinating
- pale stools
- redness, blistering, peeling, or loosening of skin
- unusual feeling in the eyes
- unusual tiredness or weakness
- yellow eyes and skin
Some side effects of thiabendazole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- dryness of eyes and mouth
- ringing or buzzing in the ears
This medicine may cause the urine to have an asparagus-like or other unusual odor while you are taking it and for about 24 hours after you stop taking it. This side effect does not need medical attention.
For Healthcare Professionals
Applies to thiabendazole: compounding powder, oral suspension, oral tablet chewable
Gastrointestinal side effects have commonly included nausea, vomiting, anorexia, and abdominal pain. These side effects generally only last 1 to 2 days and do not require drug discontinuation. Epigastric distress and abdominal pain have also been reported.
Nervous system side effects have included drowsiness, dizziness, giddiness, headache, paresthesias, weariness, numbness, hyperirritability, convulsions, collapse, confusion, depression, floating sensation, weakness, and lack of coordination.
Erythema multiforme (including Stevens-Johnson syndrome) and toxic epidermal necrolysis generally do not occur for several weeks after thiabendazole is discontinued. The reaction generally starts with a skin eruption which quickly progresses. Two reported cases had complete recovery after several weeks of therapy.
Hypersensitivity adverse effects have included pruritic rash reactions, fever, facial flush, chills, conjunctival injection, angioedema, anaphylaxis, skin rashes (including perianal), erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis, and lymphadenopathy.
Sicca complex has been frequently noted with the hepatic changes associated with thiabendazole. This clinical picture includes keratoconjunctivitis sicca and xerostomia. This also appears to be reversible in most cases without medical intervention.
Hepatic side effects reported have included liver damage. It may manifest as jaundice, cholestasis, sicca syndrome, malaise, light-colored stools, and gastrointestinal upset. These symptoms generally do not occur for several weeks following thiabendazole therapy completion. Therapy usually consists of only supportive measures. In most cases the hepatic damage is reversible, although at least one patient has died as a result of hepatic damage. Sicca complex has also been reported.
Ocular side effects have included abnormal sensation in eyes, xanthopsia, blurred vision, and transient disturbances in vision.
Cardiovascular side effects have included hypotension.
Metabolic side effects have included hyperglycemia.
Hematologic side effects have included transient leukopenia.
Genitourinary side effects have included hematuria, enuresis, malodor of the urine, and crystalluria.
Psychiatric side effects have included psychic alterations.
Other side effects have included tinnitus, drying of mucous membranes, and live Ascaris in the mouth and nose.
More thiabendazole resources
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