Thiabendazole Side Effects

It is possible that some side effects of thiabendazole may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to thiabendazole: oral suspension, oral tablet chewable

As well as its needed effects, thiabendazole may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking thiabendazole, check with your doctor immediately:

More common
  • Confusion
  • diarrhea (severe)
  • hallucinations (seeing, hearing, and feeling things that are not there)
  • irritability
  • loss of appetite
  • nausea and vomiting (severe)
  • numbness or tingling in the hands or feet
Less common
  • Skin rash or itching

If any of the following side effects occur while taking thiabendazole, check with your doctor or nurse as soon as possible:

Rare
  • Aching of joints and muscles
  • blurred or yellow vision
  • chills
  • convulsions (seizures)
  • dark urine
  • fever
  • lower back pain
  • pain or burning while urinating
  • pale stools
  • redness, blistering, peeling, or loosening of skin
  • unusual feeling in the eyes
  • unusual tiredness or weakness
  • yellow eyes and skin

Some thiabendazole side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Dizziness
  • drowsiness
  • dryness of eyes and mouth
  • headache
  • ringing or buzzing in the ears

This medicine may cause the urine to have an asparagus-like or other unusual odor while you are taking it and for about 24 hours after you stop taking it. This side effect does not need medical attention.

For Healthcare Professionals

Applies to thiabendazole: compounding powder, oral suspension, oral tablet chewable

Gastrointestinal

Gastrointestinal side effects have commonly included nausea, vomiting, anorexia, and abdominal pain. These side effects generally only last 1 to 2 days and do not require drug discontinuation. Epigastric distress and abdominal pain have also been reported.

Nervous system

Nervous system side effects have included drowsiness, dizziness, giddiness, headache, paresthesias, weariness, numbness, hyperirritability, convulsions, collapse, confusion, depression, floating sensation, weakness, and lack of coordination.

Hypersensitivity

Erythema multiforme (including Stevens-Johnson syndrome) and toxic epidermal necrolysis generally do not occur for several weeks after thiabendazole is discontinued. The reaction generally starts with a skin eruption which quickly progresses. Two reported cases had complete recovery after several weeks of therapy.

Hypersensitivity adverse effects have included pruritic rash reactions, fever, facial flush, chills, conjunctival injection, angioedema, anaphylaxis, skin rashes (including perianal), erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis, and lymphadenopathy.

Hepatic

Sicca complex has been frequently noted with the hepatic changes associated with thiabendazole. This clinical picture includes keratoconjunctivitis sicca and xerostomia. This also appears to be reversible in most cases without medical intervention.

Hepatic side effects reported have included liver damage. It may manifest as jaundice, cholestasis, sicca syndrome, malaise, light-colored stools, and gastrointestinal upset. These symptoms generally do not occur for several weeks following thiabendazole therapy completion. Therapy usually consists of only supportive measures. In most cases the hepatic damage is reversible, although at least one patient has died as a result of hepatic damage. Sicca complex has also been reported.

Ocular

Ocular side effects have included abnormal sensation in eyes, xanthopsia, blurred vision, and transient disturbances in vision.

Cardiovascular

Cardiovascular side effects have included hypotension.

Metabolic

Metabolic side effects have included hyperglycemia.

Hematologic

Hematologic side effects have included transient leukopenia.

Genitourinary

Genitourinary side effects have included hematuria, enuresis, malodor of the urine, and crystalluria.

Psychiatric

Psychiatric side effects have included psychic alterations.

Other

Other side effects have included tinnitus, drying of mucous membranes, and live Ascaris in the mouth and nose.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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