Tebamide Side Effects

Generic name: benzocaine / trimethobenzamide

Note: This document contains side effect information about benzocaine / trimethobenzamide. Some of the dosage forms listed on this page may not apply to the brand name Tebamide.

Some side effects of Tebamide may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to benzocaine / trimethobenzamide: rectal suppository

Get emergency medical help if you have any of these signs of an allergic reaction:hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

If you experience any of the following serious side effects, stop taking benzocaine and trimethobenzamide and seek emergency medical attention or contact your doctor immediately:

Stop using this medication and call your doctor at once if you have any of these serious side effects:

• jaundice (yellowing of the skin or eyes);

• seizure (convulsions); or

• easy bruising or bleeding, unusual weakness;

• tremor (uncontrolled shaking); or

• muscle cramps, severe muscle spasms.

Other less serious side effects are more likely to occur. Continue using benzocaine and trimethobenzamide and talk with your doctor if you have any of these less serious side effects:

• drowsiness or dizziness;

• headache;

• feeling depressed or disoriented; or

• blurred vision.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

For Healthcare Professionals

Applies to benzocaine / trimethobenzamide: rectal suppository

Cardiovascular

Cardiovascular side effects have included hypotension. It has been occasionally associated with intramuscular administration of trimethobenzamide in surgical patients.

Gastrointestinal

Gastrointestinal side effects have included diarrhea.

Hematologic

Hematologic side effects have rarely included blood dyscrasias. Methemoglobinemia, characterized by cyanosis, has been reported with the use of benzocaine topical.

Hepatic

Hepatic side effects have included hepatotoxicity and jaundice associated with the use of trimethobenzamide.

An isolated case report described a 50-year-old white female receiving trimethobenzamide capsules during a study protocol for use as a prophylactic antiemetic. After two days of administration, the patient had become jaundiced and her urine was dark. She felt tired, anorexic and nauseated with mild epigastric pain. A liver scan four days after the episode indicated hepatocellular dysfunction. She denied any other factors which may have contributed to the episode.

Hypersensitivity

Hypersensitivity side effects have included allergic-type skin reactions. Bronchospasm, shock, and anaphylactoid reactions may occur and, in general, have occurred with high plasma levels of the local anesthetic. Parkinson-like symptoms have been reported following the use of trimethobenzamide. These have abated following drug discontinuation, but in some cases treatment may be indicated.

Musculoskeletal

Musculoskeletal side effects have included muscle cramps associated with the use of trimethobenzamide.

Nervous system

Extrapyramidal reactions to trimethobenzamide have been reported in some patients, the youngest of whom was 2 weeks old. This patient received approximately 300 mg rectally, although the drug is not recommended for newborn infants.

Nervous system side effects have included dizziness, drowsiness, headache, disorientation, convulsions, opisthotonus, Parkinson's-like symptoms, trismus, and extrapyramidal symptoms.

Psychiatric

Psychiatric side effects have included depression.

Local

Local side effects have included burning, stinging, tenderness, and sloughing following the use of benzocaine topical. Pain has been reported following the intramuscular administration of trimethobenzamide.

Ocular

Ocular side effects have included blurred vision following the use of trimethobenzamide.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.