Rubella virus vaccine Side Effects

Some side effects of rubella virus vaccine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to rubella virus vaccine: subcutaneous powder for injection

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with measles, mumps, or rubella is much more dangerous to your health than receiving the vaccine to protect against these diseases. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely low.

Get emergency medical help if you have any of these signs of an allergic reaction while taking rubella virus vaccine: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• high fever (within a few hours or a few days after the vaccine);

• swollen glands;

• easy bruising or bleeding, unusual weakness;

• joint swelling or stiffness that continues for several weeks after vaccination;

• weakness, severe lower back pain, numbness or tingly feeling in your feet and spreading upward;

• problems with hearing, vision, speech, swallowing, or bladder and bowel functions;

• slow heart rate, trouble breathing, feeling like you might pass out;

• seizure (black-out or convulsions); or

• severe blistering, peeling, and red skin rash.

Less serious side effects include:

• low fever, sore throat, cough, runny nose;

• headache, dizziness, feeling tired or irritable;

• nausea, vomiting, diarrhea;

• joint or muscle pain;

• numbness or tingly feeling; or

• redness, pain, swelling, or a lump where the shot was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to rubella virus vaccine: subcutaneous powder for injection

Local

Local side effects have included injection site burning/stinging, wheal and flare, erythema, pain, and induration.

Hypersensitivity

Hypersensitivity reactions have included anaphylaxis, anaphylactoid reactions, angioneurotic edema (including peripheral or facial edema), and bronchial spasm.

Cardiovascular

Cardiovascular side effects have included vasculitis.

Dermatologic

Dermatologic side effects have included Stevens-Johnson Syndrome, erythema multiforme, urticaria, and rash.

Gastrointestinal

Gastrointestinal side effects have included pancreatitis; diarrhea, vomiting, and nausea.

Hematologic

Hematologic side effects have included thrombocytopenia, purpura, regional lymphadenopathy, and leukocytosis.

Musculoskeletal

Musculoskeletal side effects have included arthralgia and/or arthritis (usually transient and rarely chronic), myalgia, paresthesia, and rarely chronic arthritis; these symptoms may also occur with natural rubella.

The vaccine has rarely been associated with chronic joint symptoms. The incidence of arthritis and arthralgia is generally higher in adult women than in children (women, 12% to 26%; children, 0% to 3%), and symptoms tend to be more marked and of longer duration, persisting for months or years (rare). In adolescent girls, the incidence of reactions appears to be intermediate between those seen in children and in women. These reactions are generally well tolerated and rarely interfere with normal activities, even in women over 35 years old.

Nervous system

Nervous system side effects have included encephalitis, Guillain-Barré Syndrome (GBS), polyneuritis, polyneuropathy, and paresthesia.

Ocular

Ocular side effects have included optic neuritis, papillitis, retrobulbar neuritis, and conjunctivitis.

Other

Otic side effects have included nerve deafness and otitis media.

Respiratory

Respiratory side effects have included sore throat, cough, and rhinitis.

Other

A postmarketing surveillance study of measles/mumps/rubella vaccine in Finland during 1982 to 1993 with 1.5 million pediatric and adult vaccinees reported no deaths or permanent sequelae.

Other side effects have included fever, syncope, headache, dizziness, malaise, and irritability. Fatalities have been reported with the polyvalent measles/mumps/rubella vaccine; however, causality has not been determined.

Health care providers should report any allergic or unusual adverse reactions to the Vaccine Adverse Event Reporting System (VAERS) at 1-800-822-7967 (USA) and the manufacturer.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.