Rabies vaccine Side Effects
Please note - some side effects for Rabies vaccine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
Side Effects of Rabies vaccine - for the Consumer
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Rabies vaccine:
Seek medical attention right away if any of these SEVERE side effects occur when using Rabies vaccine:
Chills; dizziness; general body discomfort; headache; itching; mild fever; stomach pain; tiredness; weakness.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty swallowing; hoarseness; joint or muscle pain; numbness or tingling; pain, redness, or swelling at the injection site; paralysis.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.Top
Side Effects by Body System - for Healthcare Professionals
Applies to: intradermal suspension; intramuscular suspension
The most common side effects have included local injection site reactions in up to 45% of patients. The most common systemic reactions have included malaise, headache, and dizziness in up to 25% of patients. Rabies prophylaxis should not be interrupted or discontinued because of local or mild systemic reactions. These reactions usually can be managed with antipyretics and anti-inflammatories.
The risk of developing a potentially fatal rabies infection should be considered before making the decision to discontinue rabies vaccination when severe anaphylactic or neuroparalytic reactions occur. The State Health Department or Centers for Disease Control and Prevention may be consulted for advice on managing serious reactions.
Adverse reactions should be reported to the U.S. Department of Health and Human Services Vaccine Adverse Event Reporting System. Reporting forms and information regarding the completion of the form can be obtained at 1-800-822-7967 (USA).
Local side effects have included injection site erythema, induration, pain, itching, and extensive limb swelling.
Other side effects have included flu-like symptoms such as asthenia, fatigue, fever, headache, myalgia, and malaise; and lymphadenopathy, sweating, and chills.
Cardiovascular side effects have included palpitations and hot flush.
Dermatologic side effects have included rash and one case of suspected urticaria pigmentosa.
Gastrointestinal side effects have included nausea.
Hypersensitivity reactions have included anaphylaxis, type III hypersensitivity-like reactions, bronchospasm, urticaria, pruritus, and edema.
Musculoskeletal side effects have included myalgia, arthralgia, and monoarthritis.
Nervous system side effects have included dizziness, transient paresthesias, neuroparalysis, encephalitis, meningitis, transient paralysis, Guillain-Barre syndrome, myelitis, retrobulbar neuritis, multiple sclerosis, vertigo, and visual disturbance. The use of corticosteroids to treat life-threatening neuroparalytic reactions may inhibit the development of immunity to rabies.
HDCV has been associated with immune complex-like reactions after administration of booster doses. The reaction has an onset is 2 to 21 days after the booster and is characterized by angioedema, nausea, vomiting, fever, and malaise. The estimated incidence is up to 6% of patients receiving boosters.Top
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