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Propafenone Side Effects

Medically reviewed by Drugs.com. Last updated on Nov 25, 2023.

Applies to propafenone: oral capsule extended release, oral tablet.

Important warnings This medicine can cause some serious health issues

Oral route (tablet; capsule, extended release)

It is prudent to consider any Class 1C antiarrhythmic to have a significant proarrhythmic risk in patients with structural heart disease.

Given the lack of any evidence that these drugs improve survival, antiarrhythmic agents should generally be avoided in patients with non-life-threatening ventricular arrhythmias, even if the patients are experiencing unpleasant, but not life-threatening, symptoms or signs.

Common side effects of propafenone

Some side effects of propafenone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • change in taste or bitter or metallic taste

Less common

  • blurred vision
  • constipation
  • diarrhea
  • dryness of the mouth
  • headache
  • nausea or vomiting
  • skin rash
  • unusual tiredness or weakness

Serious side effects of propafenone

Along with its needed effects, propafenone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking propafenone:

Less common

  • chest pain
  • fast, irregular, or slow heartbeat
  • lightheadedness, dizziness, or fainting
  • shortness of breath
  • swelling of the feet or lower legs
  • weight gain

Rare

  • chills
  • fever
  • joint pain
  • trembling or shaking
  • weakness

For healthcare professionals

Applies to propafenone: oral capsule extended release, oral tablet.

General

Adverse reactions occurred most commonly in the cardiovascular, gastrointestinal, and nervous systems.[Ref]

Cardiovascular

Gastrointestinal

Nervous system

Respiratory

Other

Dermatologic

Genitourinary

Hepatic

Immunologic

Metabolic

Ocular

Psychiatric

Endocrine

Hematologic

Renal

Musculoskeletal

References

1. "Product Information. Rythmol (propafenone)." Knoll Pharmaceutical Company

2. (2011) "Product Information. Rythmol SR (propafenone)." GlaxoSmithKline

Further information

Propafenone side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.