Prinivil Side Effects

Generic Name: lisinopril

Note: This page contains side effects data for the generic drug lisinopril. It is possible that some of the dosage forms included below may not apply to the brand name Prinivil.

It is possible that some side effects of Prinivil may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to lisinopril: oral tablet

As well as its needed effects, lisinopril (the active ingredient contained in Prinivil) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking lisinopril, check with your doctor immediately:

More common
  • Blurred vision
  • cloudy urine
  • confusion
  • decrease in urine output or decrease in urine-concentrating ability
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • sweating
  • unusual tiredness or weakness
Less common
  • Abdominal or stomach pain
  • body aches or pain
  • chest pain
  • chills
  • common cold
  • cough
  • diarrhea
  • difficulty breathing
  • ear congestion
  • fever
  • headache
  • loss of voice
  • nasal congestion
  • nausea
  • runny nose
  • sneezing
  • sore throat
  • vomiting
Rare
  • Arm, back, or jaw pain
  • chest discomfort, tightness, or heaviness
  • fast or irregular heartbeat
  • general feeling of discomfort or illness
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • shivering
  • trouble sleeping

Some lisinopril side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common
  • Decreased interest in sexual intercourse
  • inability to have or keep an erection
  • lack or loss of strength
  • loss in sexual ability, desire, drive, or performance
  • rash
Rare
  • Acid or sour stomach
  • belching
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • feeling of constant movement of self or surroundings
  • heartburn
  • indigestion
  • muscle cramps
  • sensation of spinning
  • stomach discomfort or upset
  • swelling

For Healthcare Professionals

Applies to lisinopril: oral tablet

Cardiovascular

Hypotension is most likely in patients who are sodium and intravascular volume depleted. In large studies, patients have reported "heart pounding" and chest pain, although the relationship to lisinopril (the active ingredient contained in Prinivil) is questionable.[Ref]

Very common (10% or more): Hypotension (11%)
Common (1% to 10%): Chest pain, angina pectoris, orthostatic hypotension, palpitations
Uncommon (0.1% to 1%): Angioneurotic edema, myocardial infarction or cerebrovascular accident, palpitations, tachycardia, Raynaud's phenomenon[Ref]

Renal

Common (1% to 10%): Creatinine increased (10%)
Very rare (less than 0.01%): Renal insufficiency[Ref]

Nervous system

Very common (10% or more): Dizziness (19%)
Common (1% to 10%): Headache, syncope
Uncommon (0.1% to 1%): Paresthesias[Ref]

Respiratory

A study has revealed a significantly higher incidence of discontinuation of angiotensin converting enzyme inhibitor therapy due to cough among black patients compared with nonblack patients (9.6% vs. 2.4%).[Ref]

Common (1% to 10%): Creatinine increased (10%)
Uncommon (0.1% to 1%): Rhinitis
Very rare (less than 0.01%): Bronchospasm, sinusitis, allergic alveolitis/eosinophilic pneumonia[Ref]

Metabolic

Common (1% to 10%): Hyperkalemia
Frequency not reported: Gout, hypoglycemia in diabetic patients receiving ACE inhibitors when concurrently treated with oral antidiabetic agents or insulin[Ref]

Gastrointestinal

Common (1% to 10%): Diarrhea, nausea, vomiting
Frequency not reported: Pancreatitis, constipation, flatulence, dry mouth, taste disturbance[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Angioedema[Ref]

Dermatologic

Uncommon (0.1% to 1%): Rash, pruritus, erythema
Rare (0.01% to 0.1%): Alopecia, urticaria, psoriasis, hypersensitivity/angioedema, angioneurotic edema of the face, extremities, lips, tongue, glottis, and/or larynx
Very rare (less than 0.01%): Sweating, skin lesions, skin infections, pemphigus, toxic epidermal necrolysis, Stevens-Johnson Syndrome, erythema multiforme, cutaneous pseudolymphoma
Frequency not reported: Photosensitivity, flushing, diaphoresis[Ref]

Hematologic

Very rare (less than 0.01%): Bone marrow depression, hemolytic anemia, leukopenia/neutropenia, thrombocytopenia, decreases in hemoglobin, decreases in hematocrit[Ref]

Psychiatric

Rare (0.01% to 0.1%): Memory impairment, confusion, somnolence, irritability, nervousness, hallucinations
Very rare (less than 0.01%): Mania

Hepatic

Common (1% to 10%): Creatinine increased
Very rare (less than 0.01%): Cholestatic jaundice that progresses to fulminant hepatic necrosis and sometimes death (discontinue of therapy if jaundice or markedly elevated hepatic serum enzymes develop)

Endocrine

Very rare (less than 0.01%): Diabetes, syndrome of inappropriate antidiuretic hormone secretion (SIADH)

Other

Common (1% to 10%): Cough
Frequency not reported: Fatigue, asthenia, orthostatic effects, tinnitus, olfactory disturbance

Genitourinary

Uncommon (0.1% to 1%): Impotence
Rare (less than 0.1%): Gynecomastia
Frequency not reported: Proteinuria

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online. Available from: URL: http://www.appco.com.au/appguide/default.asp." ([2006]):

3. "Product Information. Prinivil (lisinopril)." Merck & Co, Inc, West Point, PA.

4. Cerner Multum, Inc. "Australian Product Information." O 0

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide
(web1)