Pralatrexate Side Effects

It is possible that some side effects of pralatrexate may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to pralatrexate: intravenous solution

As well as its needed effects, pralatrexate may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking pralatrexate, check with your doctor or nurse immediately:

More common
  • Black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • body aches or pain
  • chills
  • convulsions
  • cough
  • cracked lips
  • decreased urine
  • diarrhea
  • difficult or labored breathing
  • difficulty with swallowing
  • dry mouth
  • ear congestion
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • headache
  • increased thirst
  • loss of appetite
  • loss of voice
  • lower back or side pain
  • mood changes
  • muscle pain or cramps
  • nasal congestion
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • runny nose
  • shortness of breath
  • sneezing
  • sore throat
  • sores, ulcers, or white spots on the lips, tongue, or inside the mouth
  • swelling
  • tightness in the chest
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Some pralatrexate side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Abdominal or stomach pain
  • back pain
  • bloody nose
  • constipation
  • itching skin
  • lack or loss of strength
  • night sweats
  • pain in the arms or legs
  • rash
  • weight loss

For Healthcare Professionals

Applies to pralatrexate: intravenous solution

Gastrointestinal

Very common (10% or more): Mucositis (70%), nausea (40%), constipation (33%), vomiting (25%), diarrhea (21%), anorexia (15%)

Hematologic

Very common (10% or more): Thrombocytopenia (41%), anemia (34%), neutropenia (24%), leukopenia (11%)
Common (1% to 10%): Febrile neutropenia, pancytopenia

General

The most common side effects observed in patients with peripheral T-cell lymphoma (PTCL) were mucositis, thrombocytopenia, nausea, and fatigue.

Cardiovascular

Very common (10% or more): Edema (30%), tachycardia (10%)
Uncommon (0.1% to 1%): Cardiopulmonary arrest

Respiratory

Very common (10% or more): Cough (28%), epistaxis (26%), dyspnea (19%), upper respiratory tract infection (10%)

Metabolic

Very common (10% or more): Hypokalemia (15%)
Common (1% to 10%): Dehydration

Dermatologic

Very common (10% or more): Rash (15%), pruritus (14%)
Frequency not reported: Skin exfoliation, ulceration, toxic epidermal necrolysis

Other

Very common (10% or more): Fatigue (36%), pyrexia (32%), pharyngolaryngeal pain (14%), abdominal pain (12%), pain in extremity (12%), back pain (11%), night sweats (11%), asthenia (10%)

Hepatic

Very common (10% or more): Abnormal liver function tests (13%)

Immunologic

Common (1% to 10%): Sepsis

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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