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Pneumococcal 13-valent vaccine Side Effects

For the Consumer

Applies to pneumococcal 13-valent vaccine: intramuscular suspension

As well as its needed effects, pneumococcal 13-valent vaccine may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking pneumococcal 13-valent vaccine, check with your doctor or nurse immediately:

More common:
  • Fever
  • Chest pain
  • chills
  • coughing, wheezing, or shortness of breath
  • difficult or labored breathing
  • difficulty with swallowing
  • fast heartbeat
  • noisy breathing
  • seizures
  • skin itching, rash, or redness
  • sneezing
  • sore throat
  • swelling of the face, throat, or tongue
  • tightness in the chest
Incidence not known:
  • Bladder pain
  • blistering, peeling, or loosening of the skin
  • bloody or cloudy urine
  • bluish lips or skin
  • body aches or pain
  • choking
  • confusion
  • decreased urine output
  • diarrhea
  • difficult, burning, or painful urination
  • dilated neck veins
  • ear congestion
  • extreme fatigue
  • fainting
  • frequent urge to urinate
  • general feeling of discomfort or illness
  • headache
  • hives
  • irregular breathing
  • irregular heartbeat
  • itching
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • lightheadedness
  • loss of appetite
  • loss of voice
  • lower back or side pain
  • muscle aches and pains
  • nasal congestion
  • nausea
  • not breathing
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid, shallow breathing
  • red, irritated eyes
  • runny nose
  • shivering
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • sweating
  • swelling of the face, fingers, feet, or lower legs
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • trouble sleeping
  • troubled breathing
  • unusual tiredness or weakness
  • vomiting
  • weight gain

Severity: Minor

Some pneumococcal 13-valent vaccine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Decreased appetite
  • decreased sleep
  • irritability
  • red streaks on the skin
  • swelling, tenderness, or pain at the injection site
  • Abdominal or stomach pain
  • crying
  • hives or welts
  • weakness
Incidence not known:
  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, rash, redness, scarring, soreness, stinging, tingling, ulceration, or warmth at the injection site
  • burning, dry, or itching eyes
  • eye discharge or excessive tearing
  • pain
  • stomach cramps
  • tenderness

For Healthcare Professionals

Applies to pneumococcal 13-valent vaccine: intramuscular suspension


Hypersensitivity side effects have included anaphylactic/anaphylactoid reaction including shock, face edema, dyspnea, and bronchospasm.[Ref]


Local side effects have included redness, swelling, and tenderness at the injection site, injection-site dermatitis, pruritus, and urticaria.[Ref]


Dermatologic side effects have included urticaria or urticaria-like rash, angioneurotic edema, and erythema multiforme.[Ref]


Respiratory side effects have included apnea.[Ref]

Nervous system

Nervous system side effects have included seizures (including febrile seizures).[Ref]


General side effects have included fever, decreased appetite, increased sleep, decreased sleep, and irritability.[Ref]


Gastrointestinal side effects have included diarrhea and vomiting.[Ref]


1. "Product Information. Prevnar 13 (pneumococcal 13-valent vaccine)." Wyeth Laboratories, Philadelphia, PA.

It is possible that some side effects of pneumococcal 13-valent vaccine may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

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