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Panixine Side Effects

Generic Name: cephalexin

Note: This page contains side effects data for the generic drug cephalexin. It is possible that some of the dosage forms included below may not apply to the brand name Panixine.

It is possible that some side effects of Panixine may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to cephalexin: oral capsule, oral powder for suspension, oral tablet, oral tablet for suspension

As well as its needed effects, cephalexin (the active ingredient contained in Panixine) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking cephalexin, check with your doctor immediately:

More common
  • Diarrhea
Rare
  • Abdominal or stomach pain
  • blistering, peeling, or loosening of the skin
  • chills
  • clay-colored stools
  • cough
  • dark urine
  • diarrhea
  • dizziness
  • fever
  • general tiredness and weakness
  • headache
  • itching
  • joint or muscle pain
  • light-colored stools
  • loss of appetite
  • nausea and vomiting
  • rash
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • unpleasant breath odor
  • unusual tiredness or weakness
  • upper right abdominal or stomach pain
  • vomiting of blood
  • yellow eyes or skin
Incidence not known
  • Abdominal or stomach cramps or tenderness
  • back or leg pains
  • black, tarry stools
  • bleeding gums
  • bloating
  • blood in the urine or stools
  • chest pain
  • coughing up blood
  • diarrhea, watery and severe, which may also be bloody
  • difficulty with breathing or swallowing
  • fast heartbeat
  • general body swelling
  • hives
  • increased menstrual flow or vaginal bleeding
  • increased thirst
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of appetite
  • nosebleeds
  • pain
  • painful or difficult urination
  • pale skin
  • paralysis
  • pinpoint red spots on the skin
  • prolonged bleeding from cuts
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red or black, tarry stools
  • red or dark brown urine
  • shortness of breath
  • swollen or painful glands
  • tightness in the chest
  • unusual bleeding or bruising
  • unusual weight loss
  • watery or bloody diarrhea
  • wheezing

Some cephalexin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Incidence not known
  • Acid or sour stomach
  • anxiety
  • belching
  • burning feeling in the chest or stomach
  • difficulty with moving
  • dry mouth
  • heartburn
  • hives or welts
  • hyperventilation
  • indigestion
  • irregular heartbeats
  • irritability
  • itching of the vagina or genital area
  • muscle pain or stiffness
  • nervousness
  • pain during sexual intercourse
  • pain, swelling, or redness in the joints
  • redness of the skin
  • restlessness
  • seeing, hearing, or feeling things that are not there
  • shaking
  • stomach upset
  • trouble with sleeping
  • white or brownish vaginal discharge

For Healthcare Professionals

Applies to cephalexin: oral capsule, oral powder for reconstitution, oral tablet, oral tablet dispersible

General

Cephalexin is generally well-tolerated. Large studies report an overall 6% incidence of side effects, some of which may not be related to cephalexin (the active ingredient contained in Panixine) [Ref]

Hypersensitivity

Hypersensitivity side effects have included fever, urticaria, rash, eosinophilia, anaphylaxis, angioedema, contact dermatitis, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute paronychia, and hepatitis.[Ref]

Up to 20% of patients with a penicillin allergy may be allergic to cephalexin.[Ref]

Gastrointestinal

Gastrointestinal side effects have included diarrhea, nausea, vomiting, dyspepsia, abdominal cramping, anorexia, and anal pruritus. Diarrhea due to Clostridium difficile colitis has been reported with some cephalosporins.[Ref]

If diarrhea occurs and it does not resolve with discontinuation of the drug and/or institution of standard antidiarrheal therapy, pseudomembranous colitis should be suspected.[Ref]

Hepatic

Hepatic side effects have included transient elevations of liver function tests, transient hepatitis, and rare cases of cholestatic jaundice.[Ref]

Renal

Renal side effects have rarely included interstitial nephritis. Reversible fever, azotemia, pyuria and eosinophiluria are the hallmarks of cephalosporin-induced interstitial nephritis. Acute tubular necrosis has also been reported.[Ref]

Hematologic

Hematologic side effects have included eosinophilia, neutropenia, thrombocytopenia and hemolytic anemia.[Ref]

Nervous system

Nervous system side effects have included dizziness, fatigue, headache, agitation, confusion, and hallucinations. Reversible ototoxicity and vertigo, apparently due to labyrinthine disease, have been reported in a few patients with renal disease.[Ref]

Genitourinary

Genitourinary side effects have included genital pruritus, genital moniliasis, vaginitis, and vaginal discharge.[Ref]

Musculoskeletal

Musculoskeletal side effects have included arthralgia, arthritis, and joint disorder.[Ref]

Dermatologic

Dermatologic side effects have included urticaria, rash, contact dermatitis, erythema multiforme, and toxic epidermal necrolysis. Acute generalized exanthematous pustulosis has been reported.[Ref]

References

1. "Product Information. Keflex (cephalexin)." Dista Products Company, Indianapolis, IN.

2. Burt RA "A review of the drug events reported by 12,917 patients treated with cephalexin." Postgrad Med J 59 (1983): 47-50,51-3

3. Filipe P, Almeida RSLS, Rodrigo FG "Occupational allergic contact dermatitis from cephalosporins." Contact Dermatitis 34 (1996): 226

4. Moellering RC Jr, Swartz MN "The newer cephalosporins." N Engl J Med 294 (1976): 24-8

5. Milligan A, Douglas WS "Contact dermatitis to cephalexin." Contact Dermatitis 15 (1986): 91

6. Jackson H, Vion B, Levy PM "Generalized eruptive pustular drug rash due to cephalexin." Dermatology 177 (1988): 292-4

7. Dave J, Heathcock R, Fenelon L, et al "Cephalexin induced toxic epidermal necrolysis." J Antimicrob Chemother 28 (1991): 477-8

8. Harnar TJ, Dobke M, Simoni J, Ninnemann JL "Toxic epidermal necrolysis complicated by severe wound sepsis: a case study." J Burn Care Rehabil 8 (1987): 554-7

9. Baran R, Perrin C "Fixed-drug eruption presenting as an acute paronychia." Br J Dermatol 125 (1991): 592-5

10. Hogan DJ, Rooney ME "Toxic epidermal necrolysis due to cephalexin." J Am Acad Dermatol 17 (1987): 852-3

11. Raff MJ "Cephalexin in lower respiratory tract infections." Postgrad Med J 59 (1983): 32-9

12. Manoharan A, Kot T "Cephalexin-induced haemolytic anaemia." Med J Aust 147 (1987): 202

13. Ammann R, Neftel K, Hardmeier T, Reinhardt M "Cephalosporin-induced cholestatic jaundice." Lancet 2 (1982): 336-7

14. Ramakrishnan K, Scheid DC "Diagnosis and management of acute pyelonephritis in adults." Am Fam Physician 71 (2005): 933-42

15. Longstreth KL, Robbins SD, Smavatkul C, Doe NS "Cephalexin-induced acute tubular necrosis." Pharmacotherapy 24 (2004): 808-11

16. Sennesael J, Verbeelen D, Lauwers S "Ototoxicity associated with cephalexin in two patients with renal failure." Lancet 2 (1982): 1154-5

17. Wolf R, Dechner E, Ophir J, Brenner S "Cephalexin: a nonthiol drug that may induced pemphigus vulgaris." Int J Dermatol 30 (1991): 213-5

18. Holscher CM, Mauck SK, Armstrong L, Buchanan JA "Man with rash and nausea. Acute generalized exanthematous pustulosis after cephalexin use." Ann Emerg Med 58 (2011): 508, 516

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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