Panixine Side Effects

Generic name: cephalexin

Note: This document contains side effect information about cephalexin. Some of the dosage forms listed on this page may not apply to the brand name Panixine.

Some side effects of Panixine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to cephalexin: for suspension oral, oral capsule, oral powder for reconstitution, oral tablet, oral tablet dispersible

Get emergency medical help if you have any of these signs of an allergic reaction while taking cephalexin (the active ingredient contained in Panixine) hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• diarrhea that is watery or bloody;

• seizure (convulsions);

• fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;

• pale or yellowed skin, dark colored urine, fever, confusion or weakness;

• easy bruising or bleeding, unusual weakness;

• confusion, agitation, hallucinations (seeing things that are not there); or

• urinating less than usual or not at all.

Less serious side effects of cephalexin may include:

• mild nausea, vomiting, diarrhea;

• dizziness, tired feeling;

• joint pain; or

• vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to cephalexin: oral capsule, oral powder for reconstitution, oral tablet, oral tablet dispersible

General

Cephalexin is generally well-tolerated. Large studies report an overall 6% incidence of side effects, some of which may not be related to cephalexin (the active ingredient contained in Panixine)

Hypersensitivity

Up to 20% of patients with a penicillin allergy may be allergic to cephalexin (the active ingredient contained in Panixine)

Hypersensitivity side effects have included fever, urticaria, rash, eosinophilia, anaphylaxis, angioedema, contact dermatitis, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute paronychia, and hepatitis.

Gastrointestinal

Gastrointestinal side effects have included diarrhea, nausea, vomiting, dyspepsia, abdominal cramping, anorexia, and anal pruritus. Diarrhea due to Clostridium difficile colitis has been reported with some cephalosporins.

If diarrhea occurs and it does not resolve with discontinuation of the drug and/or institution of standard antidiarrheal therapy, pseudomembranous colitis should be suspected.

Hepatic

Hepatic side effects have included transient elevations of liver function tests, transient hepatitis, and rare cases of cholestatic jaundice.

Renal

Renal side effects have rarely included interstitial nephritis. Reversible fever, azotemia, pyuria and eosinophiluria are the hallmarks of cephalosporin-induced interstitial nephritis. Acute tubular necrosis has also been reported.

Hematologic

Hematologic side effects have included eosinophilia, neutropenia, thrombocytopenia and hemolytic anemia.

Nervous system

Nervous system side effects have included dizziness, fatigue, headache, agitation, confusion, and hallucinations. Reversible ototoxicity and vertigo, apparently due to labyrinthine disease, have been reported in a few patients with renal disease.

Genitourinary

Genitourinary side effects have included genital pruritus, genital moniliasis, vaginitis, and vaginal discharge.

Musculoskeletal

Musculoskeletal side effects have included arthralgia, arthritis, and joint disorder.

Dermatologic

Dermatologic side effects have included urticaria, rash, contact dermatitis, erythema multiforme, and toxic epidermal necrolysis. Acute generalized exanthematous pustulosis has been reported.

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