Normiflo Side Effects
Generic Name: ardeparin
Note: This page contains side effects data for the generic drug ardeparin. It is possible that some of the dosage forms included below may not apply to the brand name Normiflo.
For the Consumer
Applies to ardeparin: subcutaneous injectable, subcutaneous solution
As well as its needed effects, ardeparin (the active ingredient contained in Normiflo) may cause unwanted side effects that require medical attention.
Stop taking ardeparin and get emergency help immediately if any of the following effects occur:Less common:
- Bleeding gums
- coughing up blood
- deep, dark purple bruise, pain, or swelling at the place of injection
- difficulty with breathing or swallowing
- increased menstrual flow or vaginal bleeding
- prolonged bleeding from cuts
- red or black, tarry stools
- red or dark brown urine
- shortness of breath
- unexplained pain, swelling, or discomfort, especially in the chest, abdomen, joints, or muscles
- unusual bruising
- vomiting of blood or coffee ground material
- Back pain
- burning, pricking, tickling, or tingling sensation
- leg weakness
- problems with bowel or bladder function
- rash consisting of pinpoint, purple-red spots, often beginning on the legs
If any of the following side effects occur while taking ardeparin, check with your doctor or nurse as soon as possible:Less common:
- Skin rash, hives, or itching
Some ardeparin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:Less common:
- pain at the injection site
For Healthcare Professionals
Applies to ardeparin: subcutaneous solution
Dose-related hematoma and injection site hemorrhage are the most commonly reported bleeding complications and may occur at any site in the body. However, the incidence of bleeding has been low (5% to 7% of patients). Ecchymosis has also been reported.
Any unexplained decrease in blood pressure and/or hematocrit should prompt consideration of a possible hemorrhagic event.
Patients undergoing spinal/epidural anesthesia or puncture and anticoagulated or scheduled to be anticoagulated with low molecular weight heparins or heparinoids are at risk for long-term or permanent paralysis due to epidural or spinal hematoma. The risk of these events is increased by the use of indwelling epidural catheters or by concomitant use of platelet inhibitors, other anticoagulants, or drugs that affect hemostasis.
Platelet counts of less than 100,000/mm3 have occurred in 2% of ardeparin-treated patients. Anemia has been reported in greater than 5% of patients. Rarely, post-operative thrombocytosis as well as immune-type thrombocytopenia has been reported. Platelet counts should be monitored in patients receiving ardeparin (the active ingredient contained in Normiflo) [Ref]
A meta-analysis of published studies reported an overall incidence of major bleeding with low molecular weight heparins of 0.7% to 1.4%. Hematologic abnormalities also include thrombocytopenia, thrombocytosis, thrombosis, and hypochromic anemia.
Bleeding due to ardeparin can usually be controlled by discontinuing the ardeparin, applying pressure, and replacing blood volume as needed. If these measures are ineffective, or a known overdose has occurred in a bleeding patient, the manufacturer recommends that protamine sulfate may be used to neutralize the hemorrhagic effects of ardeparin. Protamine should be given at a dose of 1 mg protamine per 100 anti-Xa units of ardeparin.
Additional hemorrhagic events occurring in less than 2% of the studied population include epistaxis, gastrointestinal hemorrhage, hematemesis, hematuria, melena, petechiae, rectal hemorrhage, retroperitoneal hemorrhage, and guaiac-positive stools.
Patients previously exposed to unfractionated heparin or a low-molecular-weight heparin appear to be more susceptible to developing heparin-induced thrombocytopenia (HIT) and HIT-related thromboembolic complications (e.g., transient ischemic attack, stroke) than those who were never exposed.
Heparin-induced thrombocytopenia (HIT) is an immune-mediated, prothrombotic reaction that occurs in 0.5% to 5% of patients treated with unfractionated heparin and in less than 1% of patients treated with a low molecular weight heparin (LMWH). The decrease in platelet count associated with HIT usually begins 5 to 14 days after starting heparin. However, patients with a previous exposure to heparin may have an abrupt decrease in platelets upon restarting heparin. Patients with LMWH-induced HIT exhibit a longer delay in the onset of symptoms compared with those who develop it from unfractionated heparin. Following discontinuation, platelet counts begin to recover within 4 days, but may take more than 2 weeks in patients with high-titer HIT antibodies. Thrombocytopenia is caused by heparin-dependent IgG antibodies that bind to a specific platelet protein, platelet factor 4 (PF4). The heparin-PF4-IgG immune complex binds to platelets causing platelet activation. The activated platelets cause release of platelet-derived procoagulant microparticles, which accelerate coagulation reactions and generates thrombin. LMWHs have a high cross-reactivity with circulating heparin-PF4-IgG immune complex. Factors associated with a higher risk for developing HIT-associated thrombosis include women, nonwhites, severity of thrombocytopenia, and lower body weight. Complications associated with HIT include exacerbation of venous thromboembolism, arterial or venous thrombosis, limb gangrene, stroke, and skin necrosis. The antibodies that cause HIT will usually disappear after approximately 3 months; therefore, use of unfractionated heparin or LMWH may be considered in a patient with a history of HIT if the antibody test is negative.[Ref]
Gastrointestinal adverse effects occurred in greater than 5% of patients during initial clinical trials and included nausea, vomiting and constipation.[Ref]
Local adverse effects of subcutaneous injections include pain, erythema, and hematoma formation. Rarely, patients may experience painful, red indurations and necrosis at the injection site. Hematoma at the injection site occurs with a frequency of approximately 7%. Pruritis and rash may occur rarely.[Ref]
Hepatic adverse effects of ardeparin (the active ingredient contained in Normiflo) and other low molecular weight heparins include asymptomatic transient elevations in liver function tests (greater than 3 times the upper limit of normal) which rarely are associated with increases in bilirubin. The elevations in liver function test values are usually reversible and not clinically significant.
Hypersensitivity reactions may include urticaria and maculopapular or vesiculobullous rash.
1. Foo SY, Everett BM, Yeh RW, et al. "Prevalence of heparin-induced thrombocytopenia in patients undergoing cardiac catheterization." Am Heart J 152 (2006): 290.e1-7
2. Goldhaber SZ, Morrison RB, Diran LL, Creager MA, Lee TH Jr "Abbreviated hospitalization for deep venous thrombosis with the use of ardeparin." Arch Intern Med 158 (1998): 2325-8
3. "Product Information. Normiflo (ardeparin)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
4. Begelman SM, Hursting MJ, Aghababian RV, McCollum D "Heparin-induced thrombocytopenia from venous thromboembolism treatment." J Intern Med 258 (2005): 563-72
5. Dang CH, Durkalski VL, Nappi JM "Evaluation of treatment with direct thrombin inhibitors in patients with heparin-induced thrombocytopenia." Pharmacotherapy 26 (2006): 461-8
6. Arnold DM, Kelton JG "Heparin-induced thrombocytopenia: an iceberg rising." Mayo Clin Proc 80 (2005): 988-90
7. Das P, Ziada K, Steinhubl SR, et al. "Heparin-induced thrombocytopenia and cardiovascular diseases." Am Heart J 152 (2006): 19-26
8. Levine MN, Gent M, Hirsh J, Weitz J, Turpie AG, Powers P, Neemeh J, Willan A, Skingley P "Ardeparin (low-molecular-weight heparin) vs graduated compression stockings for the prevention of venous thromboembolism: a randomized trial in patients undergoing knee surgery." Arch Intern Med 156 (1996): 851-6
9. Marymont JH, Murphy GS, Gilbert HC "Intraoperative heparin and heparin-induced thrombocytopenia." Anesth Analg 102 (2006): 328
10. Heit JA, Berkowitz SD, Bona R, Cabanas V, Corson JD, Elliott CG, Lyons R "Efficacy and safety of low molecular weight heparin (ardeparin sodium) compared to warfarin for the prevention of venou thromboembolism after total knee replacement surgery: a double-blind dose-ranging study. Ardeparin Arthroplasty Study Group." Thromb Haemost 77 (1997): 32-8
11. Levine RL, McCollum D, Hursting MJ "How frequently is venous thromboembolism in heparin-treated patients associated with heparin-induced thrombocytopenia?" Chest 130 (2006): 681-7
It is possible that some side effects of Normiflo may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
More about Normiflo (ardeparin)
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