Methohexital Side Effects

Some side effects of methohexital may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to methohexital: intravenous powder for injection, intravenous solution

Get emergency medical help if you have any of these signs of an allergic reaction while taking methohexital: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have any of these serious side effects:

• severe burning or swelling where the medicine was injected;

• seizure (convulsions);

• numbness or tingly feeling;

• feeling like you might pass out;

• fast heart rate;

• weak or shallow breathing; or

• confusion, anxiety, or restless feeling when coming out of anesthesia.

Less serious side effects of methohexital may include:

• drowsiness;

• nausea, vomiting, stomach pain;

• chills or shivering;

• coughing, hiccups;

• muscle twitching; or

• mild skin rash or itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to methohexital: intravenous powder for injection, intravenous solution

Cardiovascular

Cardiovascular side effects have included circulatory depression, thrombophlebitis, hypotension, tachycardia, peripheral vascular collapse, and convulsions in association with cardiorespiratory arrest.

Respiratory

Respiratory side effects have included respiratory depression (including apnea), cardiorespiratory arrest, laryngospasm, bronchospasm, hiccups, and dyspnea.

Nervous system

Nervous system side effects have included headache, skeletal muscle hyperactivity (twitching), and seizures.

Psychiatric

Psychiatric side effects have included emergence delirium, restlessness, and anxiety, especially in the presence of postoperative pain.

Gastrointestinal

Gastrointestinal side effects have included nausea, emesis, salivation, and abdominal pain.

Hypersensitivity

Hypersensitivity side effects have included erythema, pruritus, urticaria, and cases of anaphylaxis.

Hepatic

Hepatic side effects have included abnormal liver function tests.

Local

Local side effects have included injury to nerves adjacent to injection site and pain at injection site.

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