Methicillin Side Effects

Not all side effects for methicillin may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Applies to methicillin: injectable powder for injection

Hematologic

Adverse hematologic effects occur in approximately 7% of treated patients and appear to be associated with higher doses given for long periods of time. Recovery generally occurs within one to two weeks.

Hematologic adverse effects reported with methicillin include neutropenia, leukopenia, and thrombocytopenia. Agranulocytosis has been reported rarely.

Hepatic

Methicillin therapy has resulted in transient increases in liver function tests.

Hypersensitivity

Hypersensitivity reactions to methicillin include rash (2% to 6%), eosinophilia (up to 38%), pruritus, fever, chills, and myalgias. Methicillin is contraindicated in patients who are allergic to penicillin.

Local

Local reactions include thrombophlebitis associated with intravenous administration, and pain at injection site if given intramuscularly.

Renal

Acute renal failure and interstitial nephritis have been associated with methicillin therapy. These problems occur most frequently after prolonged therapy (longer than ten days). Acute interstitial nephritis may be accompanied by rash, fever, dysuria, proteinuria, eosinophilia, and hematuria.

The frequency of acute interstitial nephritis is higher with methicillin than other penicillinase-resistant penicillins and has been reported in up to 17% of patients. Acute renal failure generally occurs after ten days and with doses of methicillin greater than 200 mg/kg/day. Renal function slowly returns towards normal after discontinuation of methicillin, but irreversible decreases in renal function have been observed.

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