Mephobarbital Side Effects

Brand Names: Mebaral

Please note - some side effects for Mephobarbital may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects of Mephobarbital - for the Consumer

Mephobarbital

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Mephobarbital:

Clumsiness; dizziness; drowsiness; excessive daytime drowsiness ("hangover effect"); feeling of a whirling motion; headache; lightheadedness; nausea; tired feeling; vomiting; weak bones.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; difficulty sleeping; fainting; very slow breathing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Mephobarbital Side Effects - for the Professional

Mephobarbital

The following adverse reactions and their incidence were compiled from surveillance of thousands of hospitalized patients. Because such patients may be less aware of the certain milder adverse effects of barbiturates, the incidence of these reactions may be somewhat higher in fully ambulatory patients.

More than 1 in 100 Patients. The most common adverse reactions estimated to occur at a rate of 1 to 3 patients per 100 is:

Nervous System: Somnolence.

Less than 1 in 100 Patients. Adverse reactions estimated to occur at a rate of less than 1 in 100 patients listed below, grouped by organ system, and by decreasing order of occurrence are:

Nervous System: Agitation, confusion, hyperkinesia, ataxia, CNS depression, nightmares, nervousness, psychiatric disturbance, hallucinations, insomnia, anxiety, dizziness, thinking abnormality.

Respiratory System: Hypoventilation, apnea.

Cardiovascular System: Bradycardia, hypotension, syncope.

Digestive System: Nausea, vomiting, constipation.

Other Reported Reactions: Headache, hypersensitivity reactions (angioedema, skin rashes, exfoliative dermatitis), fever, liver damage, megaloblastic anemia following chronic phenobarbital use.

Side Effects by Body System - for Healthcare Professionals

Nervous system

Nervous system side effects including primarily somnolence (1% to 3%) have been reported. Agitation, confusion, hyperkinesia, ataxia, CNS depression, nightmares, nervousness, psychiatric disturbance, hallucination, insomnia, anxiety, dizziness, and abnormal thinking have all been reported to occur in less than 1% of treated patients. Headache has been reported with chronic use.

Respiratory

Respiratory side effects including hypoventilation and apnea have been reported to occur in less than 1% of treated patients.

Cardiovascular

Cardiovascular side effects including bradycardia, hypotension, and syncope have been reported to occur in less than 1% of treated patients.

Gastrointestinal

Gastrointestinal side effects including nausea, vomiting, and constipation have been reported to occur in less than 1% of treated patients.

Hypersensitivity

Hypersensitivity side effects including angioedema, skin rashes, and exfoliative dermatitis have been reported to occur with chronic use in less than 1% of treated patients.

General

General side effects including fever have been reported to occur with chronic use in less than 1% of treated patients.

Hepatic

Hepatic side effects including liver damage have been reported to occur with chronic use in less than 1% of treated patients.

Hematologic

Hematologic side effects including megaloblastic anemia have been reported to occur with chronic use in less than 1% of treated patients.

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