Kuvan Side Effects

Please note - some side effects for Kuvan may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Kuvan - for the Consumer

Kuvan

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Kuvan:

Diarrhea; headache; nausea; runny or stuffy nose; sore throat; stomach pain; vomiting.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in the stool; chest pain; fainting; fever, chills, or persistent sore throat; numbness of an arm or leg; seizures; severe or persistent stomach pain; shortness of breath; signs of urinary tract infection (eg, back pain; difficult, frequent, or painful urination); sudden severe headache or vomiting; swelling of the hands, ankles, or feet.

Side Effects by Body System

Nervous system

Nervous system side effects including headache (15%), convulsions, exacerbation of convulsions, irritability, overstimulation, agitation, and dizziness have been reported.

Respiratory

Respiratory side effects including upper respiratory tract infection (12%), rhinorrhea (11%), cough (7%), nasal congestion (4%), and respiratory failure have been reported.

Other

Other side effects including pharyngolaryngeal pain (10%), contusion (5%), abdominal pain (5%), and postprocedural bleeding have been reported.

Gastrointestinal

Gastrointestinal side effects including diarrhea (8%), vomiting (8%), and gastrointestinal bleeding have been reported.

General

General side effects including pyrexia (7%) have been reported.

Dermatologic

Dermatologic side effects including rash (5%) have been reported.

Cardiovascular

Cardiovascular side effects including myocardial infarction and peripheral edema have been reported.

Musculoskeletal

Musculoskeletal side effects including arthralgia have been reported.

Renal

Renal side effects including polyuria have been reported.

Hepatic

Hepatic side effects including two cases of increased gamma-glutamyltransferase have been reported in non-PKU patients.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.