Skip to main content

Isovue-128 Side Effects

Generic name: iopamidol

Medically reviewed by Drugs.com. Last updated on Jun 6, 2024.

Note: This document provides detailed information about Isovue-128 Side Effects associated with iopamidol. Some dosage forms listed on this page may not apply specifically to the brand name Isovue-128.

Applies to iopamidol: injection solution.

Important warnings This medicine can cause some serious health issues

Injection route (solution)

Not for intrathecal use

Serious side effects of Isovue-128

Along with its needed effects, iopamidol (the active ingredient contained in Isovue-128) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking iopamidol:

Less common

  • arm, back, or jaw pain
  • blurred vision
  • chest pain or discomfort
  • chest tightness or heaviness
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast or irregular heartbeat
  • feeling of warmth
  • hives
  • lightheadedness, dizziness, or fainting
  • nausea
  • redness of the face, neck, arms, and occasionally, upper chest
  • slow or irregular heartbeat
  • sudden sweating
  • trouble breathing
  • unusual tiredness or weakness

Less common or rare

  • blue lips and fingernails
  • changes in skin color
  • chills
  • coughing that sometimes produces a pink frothy sputum
  • decrease in the frequency of urination
  • decrease in urine volume
  • difficulty in passing urine (dribbling)
  • dizziness
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • headache
  • hives or welts, itching, or skin rash
  • increased sweating
  • nervousness
  • numbness or tingling in the face, arms, or legs
  • pain or discomfort in the arms, jaw, back, or neck
  • pain, tenderness, or swelling of the foot or leg
  • painful urination
  • pale skin
  • pounding in the ears
  • redness of the skin
  • severe, unusual tiredness or weakness
  • trouble speaking, thinking, or walking
  • vomiting

Rare

  • double vision
  • inability to move the arms, legs, or facial muscles
  • pain in the chest, groin, or legs, especially the calves
  • severe, sudden headache
  • slow speech
  • slurred speech
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • vision changes

Incidence not known

  • bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • change in consciousness
  • heart stops
  • loss of consciousness
  • no breathing
  • no pulse or blood pressure
  • no sensation in the legs
  • not able to pass urine
  • seizures
  • unable to move the legs

Other side effects of Isovue-128

Some side effects of iopamidol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare

  • bad, unusual, or unpleasant (after) taste
  • change in taste
  • discouragement
  • disturbed color perception
  • feeling sad or empty
  • halos around lights
  • irritability
  • loss of appetite
  • loss of interest or pleasure
  • loss of vision
  • night blindness
  • overbright appearance of lights
  • stuffy nose
  • trouble concentrating
  • trouble sleeping
  • tunnel vision
  • weight loss

Incidence not known

  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • burning, dry, or itching eyes
  • discharge or excessive tearing
  • general feeling of discomfort or illness
  • loss of memory
  • problems with memory
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • runny nose
  • sneezing
  • stomach cramps
  • trembling or shaking of the hands or feet

For healthcare professionals

Applies to iopamidol: injectable solution, intrathecal solution.

General

The most commonly reported adverse reactions after oral administration of this drug are vomiting and diarrhea.

If administered intrathecally, the most frequently reported adverse reactions are headache, nausea, vomiting, and musculoskeletal pain . These reactions are usually mild to moderate, occur 1 to 10 hours after injection (almost all occurring within 24 hours), and usually disappearing within 24 hours.[Ref]

Gastrointestinal

Cardiovascular

Nervous system

Other

Dermatologic

Genitourinary

Musculoskeletal

Ocular

Renal

Respiratory

Endocrine

Hematologic

Hypersensitivity

Local

Psychiatric

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics."

2. (2007) "Product Information. Isovue-M-200 (iopamidol)." Bracco Diagnostics Inc

3. Cerner Multum, Inc. "Australian Product Information."

Further information

Isovue-128 side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.