Isoflurane Side Effects

Brand Names: Forane

Please note - some side effects for Isoflurane may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Isoflurane Side Effects - for the Professional

Isoflurane

Adverse reactions encountered in the administration of Isoflurane, USP are in general dose dependent extensions of pharmacophysiologic effects and include respiratory depression, hypotension and arrhythmias.Shivering, nausea, vomiting and ileus have been observed in the postoperative period.As with all other general anesthetics, transient elevations in white blood count have been observed even in the absence of surgical stress. See WARNINGS for information regarding malignant hyperthermia and elevated carboxyhemoglobin levels.During marketing, there have been rare reports of mild, moderate and severe (some fatal) postoperative hepatic dysfunction and hepatitis.Isoflurane USP has also been associated with perioperative hyperkalemia.There have been rare post-marketing reports of hepatic failure and hepatic necrosis associated with the use of potent volatile anesthetic agents, including Isoflurane USP. Due to the spontaneous nature of these reports, the actual incidence and relationship of Isoflurane USP to these events cannot be established with certainty Top

Side Effects by Body System - for Healthcare Professionals

General

General side effects including malignant hyperthermia and shivering have been observed in the postoperative period.

In general, side effects encountered in the administration of isoflurane are dose dependent extensions of pharmacophysiologic effects and include respiratory depression, hypotension, and arrhythmias.

Hepatic

Hepatic side effects have included rare reports of mild, moderate, and severe (sometimes fatal) postoperative hepatic dysfunction and hepatitis. There have also been rare postmarketing reports of hepatic failure and hepatic necrosis associated with the use of potent volatile anesthetic agents, including isoflurane.

Gastrointestinal

Gastrointestinal side effects including nausea, vomiting, and ileus have been observed in the postoperative period.

Respiratory

Isoflurane can react with desiccated carbon dioxide (CO2) absorbents to produce carbon monoxide, which may result in elevated levels of carboxyhemoglobin in some patients.

Respiratory side effects including elevated carboxyhemoglobin levels have been reported.

Metabolic

Metabolic side effects including perioperative hyperkalemia have been reported.

Hematologic

Hematologic side effects including transient elevations in white blood count have been reported even in the absence of surgical stress.

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