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Isochron Side Effects

Generic Name: isosorbide dinitrate

Note: This page contains information about the side effects of isosorbide dinitrate. Some of the dosage forms included on this document may not apply to the brand name Isochron.

Not all side effects for Isochron may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to isosorbide dinitrate: capsule extended release, tablet, tablet chewable, tablet extended release

In addition to its needed effects, some unwanted effects may be caused by isosorbide dinitrate (the active ingredient contained in Isochron). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking isosorbide dinitrate:

Rare
  • Bluish-colored lips, fingernails, or palms
  • dark urine
  • difficulty with breathing
  • dizziness or lightheadedness
  • fever
  • headache
  • pale skin
  • rapid heart rate
  • sore throat
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Incidence not known
  • Arm, back, or jaw pain
  • blurred vision
  • chest pain or discomfort
  • chest tightness or heaviness
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • fast or irregular heartbeat
  • sweating

If any of the following symptoms of overdose occur while taking isosorbide dinitrate, get emergency help immediately:

Symptoms of overdose
  • Blurred or loss of vision
  • bulging soft spot on the head of an infant
  • change in consciousness
  • change in the ability to see colors, especially blue or yellow
  • cold, clammy skin
  • convulsions
  • disturbed color perception
  • double vision
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling of constant movement of self or surroundings
  • halos around lights
  • headache, severe and throbbing
  • increased sweating
  • loss of appetite
  • loss of consciousness
  • nausea
  • night blindness
  • overbright appearance of lights
  • paralysis
  • sensation of spinning
  • slow heartbeat
  • tunnel vision
  • vomiting

For Healthcare Professionals

Applies to isosorbide dinitrate: oral capsule extended release, oral tablet, oral tablet chewable, oral tablet extended release, sublingual tablet

General

The most common side effect was headache.[Ref]

Nervous system

Frequency not reported: Headache, dizziness, syncope, lightheadedness[Ref]

Cardiovascular

Common (1% to 10%): Decrease in blood pressure and/or orthostatic hypotension with reflex tachycardia and symptoms/signs of cerebral ischemia (including drowsiness and dizziness and weakness) with first time use and when the dose is increased
Uncommon (0.1% to 1%): Marked decreases in blood pressure with an aggravation of symptomatic angina pectoris, collapse associated with bradycardia and cardiac rhythm disturbances
Frequency not reported: Pallor, crescendo angina, rebound hypertension, hypotension[Ref]

Other

Common (1% to 10%): Peripheral edema in patients treated for left ventricular failure[Ref]

Dermatologic

Uncommon (0.1% to 1%): Allergic skin reactions
Very rare (less than 0.01%): Exfoliative dermatitis/Stevens-Johnson Syndrome or angioedema
Frequency not reported: Cutaneous vasodilation with flushing, excessive perspiration, rash[Ref]

Gastrointestinal

Uncommon (0.1% to 1%): Nausea and vomiting
Frequency not reported: Heartburn[Ref]

Endocrine

Very rare (less than 0.01%): Pituitary apoplexy in patients with undiagnosed pituitary tumors[Ref]

Ocular

Very rare (less than 0.01%): Angle closure glaucoma[Ref]

Respiratory

Very rare (less than 0.01%): Alveolar hypoventilation with consequent hypoxemia and the risk of developing a myocardial infarction in patients with coronary heart disease[Ref]

Hematologic

Frequency not reported: Methemoglobinemia, hemolytic anemia in patients with glucose-6-phosphate dehydrogenase-deficient syndrome[Ref]

Psychiatric

Frequency not reported: Restlessness[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Isordil (isosorbide dinitrate)." Wyeth-Ayerst Laboratories, Philadelphia, PA.

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