Inspra Side Effects

Generic Name: eplerenone

Note: This document contains side effect information about eplerenone. Some of the dosage forms listed on this page may not apply to the brand name Inspra.

Some side effects of Inspra may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to eplerenone: oral tablet

Along with its needed effects, eplerenone (the active ingredient contained in Inspra) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking eplerenone:

Less common
  • Excess of cholesterol in the blood
  • excess of triglycerides in the blood
Incidence not known
  • Abdominal or stomach pain
  • arm, back, or jaw pain
  • chest pain or discomfort
  • chest tightness or heaviness
  • confusion
  • difficulty with breathing
  • dizziness
  • fast or irregular heartbeat
  • headache
  • irregular heartbeat
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • nausea
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • pain or discomfort in the arms, jaw, back, or neck
  • rash
  • shortness of breath
  • sweating
  • vomiting
  • weakness or heaviness of the legs

Some side effects of eplerenone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Abnormal vaginal bleeding
  • breast pain
  • chills
  • cloudy urine
  • cough
  • diarrhea
  • fever
  • general feeling of discomfort or illness
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • swelling of the breasts or breast soreness in both females and males
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to eplerenone: oral tablet

Metabolic

Metabolic side effects have included hyperkalemia (>5.5 mEq/L). Hyperkalemia was observed in 2.6% of patients with creatinine clearance greater than 100 mL/min, in 5.6% of patients with creatinine clearance of 70 to 100 mL/min, and in 10.4% of patients with creatinine clearance less than 70 mL/min. The principal risk of eplerenone (the active ingredient contained in Inspra) is hyperkalemia, which can result in serious, sometimes fatal arrhythmias.

Other metabolic side effects have included hypercholesterolemia and hypertriglyceridemia in 1% of patients.

Nervous system

Nervous system side effects have included dizziness (3%) and headache. In a pharmacokinetic study, headache was reported in 14% to 63% of patients.

General

General side effects have included fatigue and influenza-like symptoms.

Renal

Renal side effects have included albuminuria in 1% of patients.

Respiratory

Respiratory side effects have included cough in 2% of patients.

Gastrointestinal

Gastrointestinal side effects have included diarrhea in 2% and abdominal pain in 1% of patients.

Endocrine

Endocrine side effects have included gynecomastia (up to 1%) and mastodynia (up to 1.3%) of male patients. Abnormal vaginal bleeding was reported in 2.5% of female patients.

Hepatic

Hepatic side effects have included increases in serum alanine aminotransferase (ALT) and gamma glutamyl transpeptidase (GGT).

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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