Increlex Side Effects

Generic name: mecasermin

Note: This document contains side effect information about mecasermin. Some of the dosage forms listed on this page may not apply to the brand name Increlex.

Some side effects of Increlex may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to mecasermin: subcutaneous solution

Get emergency medical help if your child has any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your child's face, lips, tongue, or throat.

Call your doctor at once if your child has a serious side effect such as:

• blurred vision, severe headache or pain behind the eyes, sometimes with vomiting;

• pain in the hip or knee, walking with a limp;

• seizure (convulsions); or

• swollen tonsils -- snoring, breathing problems during sleep, pain or fullness in your ear, hearing problems.

Less serious side effects of mecasermin (the active ingredient contained in Increlex) may include:

• dizziness;

• joint pain;

• thickening of facial skin;

• easy bruising; or

• pain, redness, bruising, or skin changes where the injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to mecasermin: subcutaneous solution

Local

Local side effects have included lipohypertrophy and bruising.

Cardiovascular

Cardiovascular side effects have included cardiac murmur.

Gastrointestinal

Gastrointestinal side effects have included vomiting.

Hematologic

Hematologic side effects have included thymus hypertrophy.

Musculoskeletal

Musculoskeletal side effects have included arthralgia and pain in extremities. Slipped capital femoral epiphysis and progression of scoliosis has been reported.

Respiratory

Respiratory side effects have included snoring and tonsillar hypertrophy.

Metabolic

Metabolic side effects have included hypoglycemia.

Other

Other side effects have included otitis media, serous otitis media, hypoacusis, fluid in middle ear, ear pain and abnormal tympanometry.

Nervous system

Nervous system side effects have included headache, dizziness, and convulsions. Intracranial hypertension has been reported.

Hypersensitivity

Hypersensitivity side effects have included anaphylaxis, generalized urticaria, angioedema, and dyspnea.

Dermatologic

Dermatologic side effects have included postmarketing reports of alopecia and abnormal hair texture.

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