Hexalen Side Effects
Generic Name: altretamine
Note: This page contains information about the side effects of altretamine. Some of the dosage forms included on this document may not apply to the brand name Hexalen.
Not all side effects for Hexalen may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
For the Consumer
Applies to altretamine: oral capsule
In addition to its needed effects, some unwanted effects may be caused by altretamine (the active ingredient contained in Hexalen). In the event that any of these side effects do occur, they may require medical attention.
Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia. Discuss these possible effects with your doctor.
You should check with your doctor immediately if any of these side effects occur when taking altretamine:Less common or rare
- Black, tarry stools
- blood in urine or stools
- cough or hoarseness, accompanied by fever or chills
- fever or chills
- lower back or side pain, accompanied by fever or chills
- painful or difficult urination, accompanied by fever or chills
- pinpoint red spots on skin
- unusual bleeding or bruising
- unusual tiredness
If any of the following side effects occur while taking altretamine, check with your doctor or nurse as soon as possible:More common
- convulsions (seizures)
- mental depression
- numbness in arms or legs
- Skin rash or itching
Some of the side effects that can occur with altretamine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:More common
- Nausea and vomiting
- loss of appetite
- stomach cramps
For Healthcare Professionals
Applies to altretamine: oral capsule
Gastrointestinal side effects include nausea and vomiting (33%), and increased alkaline phosphatase (9%).[Ref]
Nervous system side effects include peripheral sensory neuropathy (31%), anorexia and fatigue (1%), and seizures (1%).[Ref]
Hematologic side effects include anemia (33%), thrombocytopenia (9%), and leukopenia (5%).[Ref]
Renal side effects include serum creatinine levels of 1.6 to 3.75 mg/dl (7%) and increased blood urea nitrogen levels (9%).[Ref]
1. "Product Information. Hexalen Capsules (altretamine)." US Bioscience, West Conshohoken, PA.
2. Wharton JT "Hexamethylmelamine (altretamine) activity as a single agent in previously untreated advanced ovarian cancer." Cancer Treat Rev 18(suppl a) (1991): 15-21
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