Guaifenesin / phenylephrine / pyrilamine Side Effects

Not all side effects for guaifenesin / phenylephrine / pyrilamine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to guaifenesin / phenylephrine / pyrilamine: suspension, tablets

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; excitability; headache; loss of appetite; nausea; nervousness or anxiety; trouble sleeping; upset stomach; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur while taking guaifenesin / phenylephrine / pyrilamine:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; tremor; trouble sleeping; vision changes.

For Healthcare Professionals

Applies to guaifenesin / phenylephrine / pyrilamine: oral suspension, oral tablet

Nervous system

Nervous system side effects have included nervousness, restlessness, headache, drowsiness, and sedation.[Ref]

Gastrointestinal

Gastrointestinal side effects have included nausea and vomiting.[Ref]

Dermatologic

Dermatologic side effects have included rash, in addition to urticaria.[Ref]

General

General side effects have included dryness of mucous membranes.[Ref]

References

1. "Product Information. Ryna-12X (guaifenesin / phenylephrine / pyrilamine)." MedPointe Healthcare Inc, Somerset, NJ.

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