Glofitamab Side Effects

Medically reviewed by Drugs.com. Last updated on Jul 3, 2023.

Applies to glofitamab: intravenous solution.

Serious side effects of Glofitamab

Along with its needed effects, glofitamab may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking glofitamab:

More common

• Bloating or swelling of the face, arms, hands, lower legs, or feet
• burning, numbness, tingling, or painful sensations
• chest pain
• cough
• difficulty in moving
• dizziness or lightheadedness
• feeling of constant movement of self or surroundings
• headache
• joint or bone pain
• muscle cramps, pains, or stiffness
• pain or swelling at the site of the tumor
• rapid or irregular heartbeat
• rapid weight gain
• sensation of spinning
• swollen joints
• tender or swollen lymph nodes
• tingling of the hands or feet
• trembling and shaking of hands
• trouble breathing
• unsteadiness or awkwardness
• unusual weight gain or loss
• weakness
• weakness in arms, hands, legs, or feet

Less common

• Black, tarry stools
• chest tightness
• confusion as to time, place, or person
• fever or chills
• hallucinations
• holding false beliefs that cannot be changed by fact
• lower back or side pain
• mental depression or anxiety
• nightmares or unusually vivid dreams
• painful or difficult urination
• pale skin
• sleepiness or unusual drowsiness
• sneezing
• sore throat
• ulcers, sores, or white spots in the mouth
• unusual bleeding or bruising
• unusual excitement, nervousness, or restlessness
• unusual tiredness or weakness

Other side effects of Glofitamab

Some side effects of glofitamab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Back pain
• blistering, crusting, irritation, itching, or reddening of the skin
• constipation
• cracked, dry, or scaly skin
• diarrhea
• neck pain
• pain in the arms or legs
• stomach pain
• swelling

For Healthcare Professionals

Applies to glofitamab: intravenous solution.

General

The most common adverse reactions were cytokine release syndrome (CRS), fatigue, musculoskeletal pain, and rash. Serious adverse reactions occurred in 48% of patients and fatal reactions in 5%. These fatal reactions include COVID-19, sepsis, and delirium.^[Ref]

Dermatologic

Very common (10% or more): Rash (includes rash pruritic, erythema, palmar erythema, rash erythematous, rash maculopapular, pruritus, dermatitis, dermatitis acneiform, and dermatitis exfoliative) (20%)^[Ref]

Gastrointestinal

Very common (10% or more): Abdominal pain (includes abdominal discomfort, pain, and upper abdominal pain) (10%), diarrhea (14%), nausea (10%), constipation (14%)

Frequency not reported: Gastrointestinal hemorrhage^[Ref]

Hematologic

Very common (10% or more): Decreased lymphocyte count (90%), decreased hemoglobin (72%), decreased neutrophils (56%), decreased platelets (56%)^[Ref]

Immunologic

Very common (10% or more): Cytokine release syndrome (70%)^[Ref]

Musculoskeletal

Very common (10% or more): Musculoskeletal pain (includes back pain, bone pain, flank pain, myalgia, neck pain, and pain in extremity) (21%)^[Ref]

Nervous system

Very common (10% or more): Headache (10%)

Frequency not reported: Tremor, peripheral neuropathy^[Ref]

Oncologic

Very common (10% or more): Tumor flare (12%)

Frequency not reported: Tumor lysis syndrome^[Ref]

Other

Very common (10% or more): Fatigue (20%), pyrexia (16%), edema including peripheral edema and face swelling (10%), decreased sodium (49%), decreased phosphate (69%), decreased potassium (32%), decreased fibrinogen (84%), decreased calcium (48%), increased gamma-glutamyl transferase (33%), increased uric acid (23%)

Frequency not reported: Infections (includes sepsis, COVID-19, pneumonia, upper respiratory tract infections, herpes zoster, and myelitis), febrile neutropenia^[Ref]

Psychiatric

Common (1% to 10%): Mental status change^[Ref]

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer