Folotyn Side Effects

Generic Name: pralatrexate

Note: This document contains side effect information about pralatrexate. Some of the dosage forms listed on this page may not apply to the brand name Folotyn.

Some side effects of Folotyn may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to pralatrexate: intravenous solution

Along with its needed effects, pralatrexate (the active ingredient contained in Folotyn) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking pralatrexate:

More common
  • Black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • body aches or pain
  • chills
  • convulsions
  • cough
  • cracked lips
  • decreased urine
  • diarrhea
  • difficult or labored breathing
  • difficulty with swallowing
  • dry mouth
  • ear congestion
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • headache
  • increased thirst
  • loss of appetite
  • loss of voice
  • lower back or side pain
  • mood changes
  • muscle pain or cramps
  • nasal congestion
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • runny nose
  • shortness of breath
  • sneezing
  • sore throat
  • sores, ulcers, or white spots on the lips, tongue, or inside the mouth
  • swelling
  • tightness in the chest
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Some side effects of pralatrexate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Abdominal or stomach pain
  • back pain
  • bloody nose
  • constipation
  • itching skin
  • lack or loss of strength
  • night sweats
  • pain in the arms or legs
  • rash
  • weight loss

For Healthcare Professionals

Applies to pralatrexate: intravenous solution

Gastrointestinal

Gastrointestinal side effects including mucositis (70%), nausea (40%), constipation (33%), vomiting (25%), diarrhea (21%), and anorexia (15%) have been reported.

Hematologic

Hematologic side effects including thrombocytopenia (41%), anemia (34%), neutropenia (24%), and leukopenia (11%) have been reported.

General

General side effects including fatigue (36%), pyrexia (32%), and asthenia (10%) have been reported.

Cardiovascular

Cardiovascular side effects including edema (30%) and tachycardia (10%) have been reported.

Respiratory

Respiratory side effects including cough (28%), epistaxis (26%), dyspnea (19%), and upper respiratory tract infection (10%) have been reported.

Metabolic

Metabolic side effects including hypokalemia (15%) have been reported.

Dermatologic

Dermatologic side effects including rash (15%), pruritus (14%), mucositis, skin exfoliation, ulceration, and toxic epidermal necrolysis have been reported.

Other

Other side effects including pharyngolaryngeal pain (14%), abdominal pain (12%), pain in extremity (12%), back pain (11%), and night sweats (11%) have been reported.

Hepatic

Hepatic side effects including abnormal liver function tests (13%) have been reported.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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