Eylea Side Effects

Generic Name: aflibercept ophthalmic

Note: This page contains information about the side effects of aflibercept ophthalmic. Some of the dosage forms included on this document may not apply to the brand name Eylea.

Not all side effects for Eylea may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to aflibercept ophthalmic: intraocular solution

Along with its needed effects, aflibercept ophthalmic (the active ingredient contained in Eylea) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking aflibercept ophthalmic:

More common
  • Blindness
  • bloody eye
  • blurred vision
  • eye or eyelid redness
  • eye pain
  • seeing flashes, sparks of light, or a veil or curtain
  • seeing floating spots before the eyes
  • vision changes
Less common
  • Bleeding or pain at the injection site
  • swelling of the eyelid
  • Fast heartbeat
  • fever
  • headache
  • hives
  • hoarseness
  • itching
  • joint pain, stiffness, or swelling
  • rash or skin redness
  • swelling of the face, lips, hands, or feet
  • troubled breathing or swallowing
Incidence not known
  • Pain in the chest, groin, or legs, especially the calves
  • severe, sudden headache
  • slurred speech
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • sudden, unexplained shortness of breath

Some side effects of aflibercept ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Feeling like something is in the eye
  • watery eyes

For Healthcare Professionals

Applies to aflibercept ophthalmic: intraocular solution


Ocular side effects have included endophthalmitis, retinal detachments, conjunctival hemorrhage, eye pain, cataract, vitreous detachment, vitreous floaters, and increased intraocular pressure. Conjunctival hyperemia, corneal erosion, detachment of the retinal pigment epithelium, foreign body sensation in eyes, increased lacrimation, blurred vision, retinal pigment epithelium tear, eyelid edema, corneal edema have also been reported.


Local side effects have included injection site hemorrhage and injection site pain.


Cardiovascular side effects of intravitreal use of VEGF inhibitors have included arterial thromboembolic events such as nonfatal stroke, nonfatal myocardial infarction, or vascular death.

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