Durlobactam / sulbactam Side Effects

Medically reviewed by Drugs.com. Last updated on Aug 28, 2023.

Applies to durlobactam / sulbactam: intravenous powder for solution.

Serious side effects

Along with its needed effects, durlobactam / sulbactam may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking durlobactam / sulbactam:

More common

• Agitation
• black, tarry stools
• bleeding gums
• blood in the urine or stools
• coma
• confusion
• dark urine
• decreased urine
• depression
• dizziness
• dry mouth
• diarrhea
• dizziness
• fainting
• fast, slow, or irregular heartbeat
• headache
• hostility
• increased thirst
• irregular heartbeat
• irritability
• lethargy
• loss of appetite
• mood changes
• muscle pain, cramps, or twitching
• nausea or vomiting
• numbness or tingling in the hands, feet, or lips
• pale skin
• pinpoint red spots on the skin
• rapid weight gain
• seizures
• stomach pain
• stupor
• swelling of the face, ankles, or hands
• trouble breathing
• unusual bleeding or bruising
• unusual tiredness or weakness
• yellow eyes or skin

Incidence not known

• Chest tightness
• cough
• difficulty swallowing
• hives, itching, or skin rash
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

Other side effects

Some side effects of durlobactam / sulbactam may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
• constipation

For Healthcare Professionals

Applies to durlobactam / sulbactam: intravenous powder for reconstitution.

General

The most common adverse reactions were liver test abnormalities, diarrhea, anemia, and hypokalemia.^[Ref]

Cardiovascular

Common (1% to 10%): Arrhythmia

Gastrointestinal

Very common (10% or more): Diarrhea (up to 17%)

Common (1% to 10%): Constipation

Frequency not reported: Clostridioides difficile-associated diarrhea

Hematologic

Very common (10% or more): Anemia (up to 13%)

Common (1% to 10%): Thrombocytopenia

Hepatic

Very common (10% or more): Liver test abnormalities (includes abnormal liver function test, abnormal hepatic function, increased transaminases, increased ALT, increased AST; up to 19%)

Hypersensitivity

Frequency not reported: Hypersensitivity, anaphylactic shock

Metabolic

Very common (10% or more): Hypokalemia (up to 12%)

Renal

Common (1% to 10%): Acute renal injury (includes renal impairment, increased blood creatinine, toxic nephropathy, renal failure, acute kidney injury)

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer