Duricef Side Effects
Generic Name: cefadroxil
Note: This document contains side effect information about cefadroxil. Some of the dosage forms listed on this page may not apply to the brand name Duricef.
Some side effects of Duricef may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to cefadroxil: oral capsule, oral powder for suspension, oral tablet
Along with its needed effects, cefadroxil (the active ingredient contained in Duricef) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking cefadroxil:Rare
- Black, tarry stools
- bleeding gums
- blistering, peeling, or loosening of the skin
- blood in the urine or stools
- clay-colored stools
- cough or hoarseness
- dark-colored urine
- difficulty with moving
- feeling of discomfort
- fever with or without chills
- flushing or redness of the skin
- general feeling of tiredness or weakness
- inflammation of the joints
- joint or muscle pain
- light-colored stools
- lower back or side pain
- muscle aches
- muscle pain or stiffness
- painful or difficult urination
- pinpoint red spots on the skin
- red skin lesions, often with a purple center
- red, irritated eyes
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- stomach pain, continuing
- swollen lymph glands
- unusual bleeding or bruising
- unusually warm skin
- yellow eyes or skin
- Abdominal or stomach cramps or tenderness
- back, leg, or stomach pains
- chest pain
- coughing up blood
- diarrhea, watery and severe, which may also be bloody
- difficulty with breathing or swallowing
- fast heartbeat
- general body swelling
- high fever
- increased menstrual flow or vaginal bleeding
- increased thirst
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- loss of appetite
- pale skin
- prolonged bleeding from cuts
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- shortness of breath
- sudden decrease in the amount of urine
- swollen or painful glands
- tightness in the chest
- unpleasant breath odor
- unusual tiredness or weakness
- unusual weight loss
- vomiting of blood
Some side effects of cefadroxil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Rare
- Acid or sour stomach
- stomach discomfort, upset, or pain
- Hives or welts
- itching of the vagina or genital area
- itching or pain of the genital area
- pain during sexual intercourse
- redness of the skin
- thick, white vaginal discharge with no odor or with a mild odor
For Healthcare Professionals
Applies to cefadroxil: oral capsule, oral powder for reconstitution, oral tablet
Up to 20% of patients with penicillin allergy may demonstrate allergic reactions to cefadroxil (the active ingredient contained in Duricef) One study reported only 12% of patients with a confirmed allergy to amoxicillin (same side-chain as cefadroxil) showed an allergy to cefadroxil.
Hypersensitivity reactions have included urticaria, rash, erythema multiforme, Stevens-Johnson syndrome, serum sickness, angioedema, anaphylaxis, eosinophilia, and fever. Cephalosporin-class antibiotics have been associated with toxic epidermal necrolysis.
Gastrointestinal side effects have included nausea, vomiting, diarrhea, general abdominal discomfort, and dyspepsia. Pseudomembranous colitis may occur during or after treatment.
Nervous system side effects associated with some cephalosporin-class antibiotics have included seizures in renally impaired patients when the dosage was not reduced.
Renal side effects associated with cephalosporin-class antibiotics have included renal dysfunction, toxic nephropathy, elevated BUN and creatinine, interstitial nephritis, and acute tubular necrosis.
Hepatic side effects have included cholestasis, idiosyncratic hepatic failure, and elevations in serum transaminases. Cephalosporin-class antibiotics have been associated with elevated LDH, alkaline phosphatase, and bilirubin.
Genitourinary side effects have included genital pruritus, genital moniliasis, and vaginitis,
Hematologic side effects have included moderate transient neutropenia, agranulocytosis, and thrombocytopenia. Cephalosporin-class antibiotics have been associated with aplastic anemia, hemolytic anemia, hemorrhage, prolonged prothrombin time, positive Coombs' test, eosinophilia, and pancytopenia.
Cephalosporin-class antibiotics have been associated with superinfection.
Musculoskeletal side effects have included arthralgia.
More about Duricef (cefadroxil)
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