Duricef Side Effects

Generic name: cefadroxil

Note: This document contains side effect information about cefadroxil. Some of the dosage forms listed on this page may not apply to the brand name Duricef.

Some side effects of Duricef may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to cefadroxil: oral capsule, oral powder for reconstitution, oral tablet

Get emergency medical help if you have any of these signs of an allergic reaction while taking cefadroxil (the active ingredient contained in Duricef) hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• diarrhea that is watery or bloody;

• fever, chills, body aches, flu symptoms;

• unusual bleeding or bruising;

• seizure (convulsions);

• pale or yellowed skin, dark colored urine, fever, confusion or weakness;

• jaundice (yellowing of the skin or eyes);

• fever, swollen glands, rash or itching, joint pain, or general ill feeling;

• fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or

• increased thirst, loss of appetite, swelling, weight gain, feeling short of breath, urinating less than usual or not at all.

Less serious side effects of cefadroxil may include:

• nausea, vomiting, stomach pain, mild diarrhea;

• stiff or tight muscles;

• joint pain;

• feeling restless or hyperactive;

• unusual or unpleasant taste in your mouth;

• mild itching or skin rash; or

• vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

For Healthcare Professionals

Applies to cefadroxil: oral capsule, oral powder for reconstitution, oral tablet

Hypersensitivity

Up to 20% of patients with penicillin allergy may demonstrate allergic reactions to cefadroxil (the active ingredient contained in Duricef) One study reported only 12% of patients with a confirmed allergy to amoxicillin (same side-chain as cefadroxil) showed an allergy to cefadroxil.

Hypersensitivity reactions have included urticaria, rash, erythema multiforme, Stevens-Johnson syndrome, serum sickness, angioedema, anaphylaxis, eosinophilia, and fever. Cephalosporin-class antibiotics have been associated with toxic epidermal necrolysis.

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, diarrhea, general abdominal discomfort, and dyspepsia. Pseudomembranous colitis may occur during or after treatment.

Nervous system

Nervous system side effects associated with some cephalosporin-class antibiotics have included seizures in renally impaired patients when the dosage was not reduced.

Renal

Renal side effects associated with cephalosporin-class antibiotics have included renal dysfunction, toxic nephropathy, elevated BUN and creatinine, interstitial nephritis, and acute tubular necrosis.

Hepatic

Hepatic side effects have included cholestasis, idiosyncratic hepatic failure, and elevations in serum transaminases. Cephalosporin-class antibiotics have been associated with elevated LDH, alkaline phosphatase, and bilirubin.

Genitourinary

Genitourinary side effects have included genital pruritus, genital moniliasis, and vaginitis,

Hematologic

Hematologic side effects have included moderate transient neutropenia, agranulocytosis, and thrombocytopenia. Cephalosporin-class antibiotics have been associated with aplastic anemia, hemolytic anemia, hemorrhage, prolonged prothrombin time, positive Coombs' test, eosinophilia, and pancytopenia.

Other

Cephalosporin-class antibiotics have been associated with superinfection.

Musculoskeletal

Musculoskeletal side effects have included arthralgia.

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