Doxapram Side Effects
Medically reviewed by Drugs.com. Last updated on Nov 10, 2023.
Applies to doxapram: parenteral injection.
Side effects include:
Cough, dyspnea, tachypnea, headache, dizziness, apprehension, hypertension, flushing, sweating, nausea, vomiting, diarrhea, urinary retention, muscle spasticity.
For Healthcare Professionals
Applies to doxapram: intravenous solution.
General
-In preterm neonates and infants, this drug has caused significant QT interval prolongation (associated with atrioventricular block in some cases), bloody stools, abdominal distension, necrotizing enterocolitis, multiple gastric perforations/increased gastric residuals, neurodevelopmental delay, vomiting, premature teeth eruption, hypertension, irritability, jitteriness, hyperglycemia, glucosuria, erratic limb movements, excessive crying, and disturbed sleep.
-Seizures have occurred in premature neonates with risk factors such as a previous seizure, perinatal asphyxia, or intracerebral hemorrhage. In many cases, this drug was given following administration of xanthine derivatives (e.g., caffeine, aminophylline, or theophylline).[Ref]
Cardiovascular
Frequency not reported: Phlebitis, heart rate variations, lowered T-waves, arrhythmia, ventricular tachycardia, sinus tachycardia, ventricular fibrillation, bradycardia, extrasystole, chest pain, chest tightness, increased blood pressure, flushing[Ref]
Dermatologic
Frequency not reported: Pruritus, sweating[Ref]
Gastrointestinal
Frequency not reported: Nausea, vomiting, diarrhea, defecation desire, salivation[Ref]
Genitourinary
Frequency not reported: Urinary retention, urinary bladder stimulation with spontaneous voiding, elevated BUN, albuminuria[Ref]
Hematologic
Frequency not reported: Hemolysis, decreased hemoglobin, decreased hematocrit, decreased red blood cell count, decreased white blood cell count (in presence of pre-existing leukopenia)[Ref]
Musculoskeletal
Frequency not reported: Muscle spasticity, muscle fasciculation, increased deep tendon reflexes, clonus, bilateral Babinski[Ref]
Nervous system
Frequency not reported: Paresthesia, headache, dizziness, hyperactivity, involuntary movement, convulsion, decreased cerebral blood flow velocity[Ref]
Ocular
Frequency not reported: Pupillary dilation[Ref]
Other
Frequency not reported: Pyrexia, perineal warmth[Ref]
Psychiatric
Frequency not reported: Apprehension, disorientation, hallucination, confusion[Ref]
Respiratory
Frequency not reported: Dyspnea, cough, hyperventilation, tachypnea, laryngospasm, bronchospasm, hiccough, rebound hyperventilation[Ref]
More about doxapram
- doxapram consumer information
- Check interactions
- Compare alternatives
- Side effects
- Dosage information
- During pregnancy
- Drug class: CNS stimulants
Professional resources
Other brands
Related treatment guides
References
1. Product Information. Dopram (doxapram). West Ward Pharmaceutical Corporation. 2001;PROD.
2. Cerner Multum, Inc. UK Summary of Product Characteristics.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.
