Deferoxamine Side Effects
Some side effects of deferoxamine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to deferoxamine: injection powder for solution
Along with its needed effects, deferoxamine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking deferoxamine:More common
- Bluish fingernails, lips, or skin
- blurred vision or other problems with vision
- convulsions (seizures)
- difficulty with breathing or fast breathing
- fast heartbeat
- hearing problems
- redness or flushing of the skin
- difficult urination
- leg cramps
- stomach and muscle cramps
- stomach discomfort
- unusual bleeding or bruising
- decreased urine output
- difficulty with swallowing
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- muscle twitching
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid weight gain
- shortness of breath
- skin rash
- swelling of the face, ankles, or hands
- tightness in the chest
- unusual tiredness or weakness
Some side effects of deferoxamine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Incidence not known
- Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
For Healthcare Professionals
Applies to deferoxamine: injectable powder for injection
Local side effects include localized irritation, pain, burning, swelling, induration, infiltration, pruritus, erythema, wheal formation, eschar, crust, vesicles, and local edema.
Injection site reactions are sometimes associated with systemic reactions like arthralgia, fever, headache, myalgia, nausea, vomiting, abdominal pain and/or asthma.
Cardiovascular side effects include tachycardia, hypotension, and shock.
Musculoskeletal side effects include leg cramps, arthralgia, and myalgia. Growth retardation and bone changes are common in chelated patients at doses above 60 mg/kg, especially in children who begin iron chelation before four years of age. However, the risk is reduced considerably if the dose is 40 mg/kg or below. A case of pelvic osteomyelitis has also been reported.
Nervous system side effects include dizziness, peripheral sensory, motor, or mixed neuropathy, paresthesias, exacerbation or precipitation of aluminum related dialysis encephalopathy.
Dermatologic side effects include generalized rash, urticaria, and angioedema.
Gastrointestinal side effects include abdominal discomfort, diarrhea, nausea, and vomiting.
Hematologic side effects including thrombocytopenia and leukopenia have been reported.
Respiratory side effects include acute respiratory distress syndrome with dyspnea, cyanosis, and/or interstitial infiltrates.
Genitourinary side effects include dysuria and impaired renal function.
General side effects include fever, headache, and abdominal pain.
Otic side effects include clinical deafness, high frequency sensorineural hearing loss, and tinnitus.
Postmarketing reports suggest that there may be an increased risk of deafness and hearing loss in the geriatric population.
Ocular side effects include decreased acuity, blurred vision, loss of vision, dyschromatopsia, night blindness, visual field defects, scotoma, retinopathy (pigmentary degeneration), optic neuritis, and cataracts.
Postmarketing reports suggest a possible trend for an increased risk of eye disorders in the geriatric population, specifically the occurrence of color blindness, maculopathy, and scotoma.
Although the number of reports was very small, certain elderly patients may be predisposed to eye disorders when taking deferoxamine.
Immunologic side effects rarely include enhanced susceptibility to Yersinia enterocolitica and Yersinia pseudotuberculosis. Very rare cases of mucormycosis have also been reported.
Renal side effects in postmarketing experience have included increases in serum creatinine (possibly dose-related), acute renal failure and renal tubular disorders.
Hepatic side effects have included hepatic dysfunction.
More deferoxamine resources
- deferoxamine Concise Consumer Information (Cerner Multum)
- deferoxamine MedFacts Consumer Leaflet (Wolters Kluwer)
- deferoxamine Injection Advanced Consumer (Micromedex) - Includes Dosage Information
- Deferoxamine Prescribing Information (FDA)
- Deferoxamine Mesylate Monograph (AHFS DI)
- Desferal Prescribing Information (FDA)
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