Dantrium Side Effects
Generic name: dantrolene
Note: This document contains side effect information about dantrolene. Some of the dosage forms listed on this page may not apply to the brand name Dantrium.
Some side effects of Dantrium may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to dantrolene: oral capsule
Other dosage forms:
Along with its needed effects, dantrolene (the active ingredient contained in Dantrium) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Serious side effects are very rare when dantrolene is taken for a short time, for example, when it is used for a few days before, during, or after surgery or anesthesia to prevent or treat malignant hyperthermia. However, serious side effects may occur, especially when the medicine is taken for a long time.
Check with your doctor immediately if any of the following side effects occur while taking dantrolene:Less common
- Bloody or black, tarry stools
- bloody or dark urine
- bluish color changes in skin color
- changes in speech
- chest pain
- convulsions (seizures)
- decrease in frequency of urination
- decrease in urine volume
- difficult urination
- difficulty in moving
- difficulty in passing urine (dribbling)
- difficulty in swallowing
- fast, pounding, or irregular heartbeat or pulse
- increased frequency of urination
- increased urge to urinate during the night
- joint pain
- light-colored stools
- loss of bladder control
- mental depression
- muscle aching or cramping
- muscle pains or stiffness
- muscle spasm or jerking of all extremities
- nausea and vomiting
- pain in lower back
- pain or burning while urinating
- pain, tenderness, or changes in skin color
- painful urination
- severe stomach pain
- shortness of breath
- skin rash, hives, or itching
- slow or troubled breathing
- sudden decrease in amount of urine
- sudden loss of consciousness
- swelling of foot or leg
- swollen joints
- unusual tiredness or weakness
- upper right abdominal pain
- vomiting of blood or material that looks like coffee grounds
- waking to urinate at night
- yellow eyes or skin
Some side effects of dantrolene may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- general feeling of discomfort or illness
- muscle weakness
- Abdominal or stomach cramps or discomfort
- abnormal hair growth
- acne-like rash
- blurred or double vision or any change in vision
- change in taste
- chills and fever
- disturbed color perception
- excessive tearing
- halos around lights
- itching skin
- loss of appetite
- night blindness
- overbright appearance of lights
- redness of skin
- seeing double
- skin rash, encrusted, scaly and oozing
- slurring of speech or other speech problems
- sudden decrease in amount of urine
- trouble in sleeping
- tunnel vision
- unable to sleep
- unusual nervousness
- weight loss
For Healthcare Professionals
Applies to dantrolene: intravenous powder for injection, oral capsule
Nervous system side effects have commonly included drowsiness (30%), dizziness (14%), and malaise. Speech disturbances, headache, seizures and hallucinations have been reported less frequently.
Several reports of severe constipation and abdominal distention leading to functional obstruction have been reported.
Gastrointestinal side effects have frequently included diarrhea which may be severe enough to require discontinuation. Constipation, abdominal cramps, nausea, and vomiting have been reported less frequently.
Hematologic side effects have included aplastic anemia, leukopenia, and lymphocytic lymphoma.
Musculoskeletal side effects have commonly included weakness which is usually tolerable. Myalgia and backache have also been reported.
Hepatic side effects have included hepatic injury (1.8%), hepatitis (0.6%), and fatal hepatitis (0.3%).
Risk of hepatic injury is greater in females, patients over 35 years of age, and in patients on concurrent medications. The severity of the reaction appears to increase with increases in dose and duration.
Respiratory side effects have infrequently included pulmonary edema with the use of intravenous dantrolene (the active ingredient contained in Dantrium) Pleural effusion and pneumonitis have also been reported.
Cardiovascular side effects have infrequently included pericarditis (both with and without pleural effusion) in patients receiving oral dantrolene (the active ingredient contained in Dantrium) Cardiovascular side effects reported postmarketing have included heart failure.
Local side effects have included thrombophlebitis in patients receiving intravenous dantrolene (the active ingredient contained in Dantrium)
Dermatologic side effects have included rare reports of acne.
Ocular side effects have included visual disturbances.
Other side effects have included one case of bilateral hearing loss which was thought to have been secondary to dantrolene (the active ingredient contained in Dantrium) treatment.
Hypersensitivity side effects reported postmarketing have included anaphylaxis.
More Dantrium resources
- Dantrium Concise Consumer Information (Cerner Multum)
- Dantrium Prescribing Information (FDA)
- Dantrium MedFacts Consumer Leaflet (Wolters Kluwer)
- Dantrium Monograph (AHFS DI)
- Dantrium Advanced Consumer (Micromedex) - Includes Dosage Information
- Dantrolene Prescribing Information (FDA)
- Dantrium Intravenous Prescribing Information (FDA)
- Dantrium Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information
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