Benzocaine / trimethobenzamide Side Effects
Some side effects of benzocaine / trimethobenzamide may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to benzocaine / trimethobenzamide: suppositories
Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur while taking benzocaine / trimethobenzamide:
Dizziness; drowsiness; rectal irritation.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); loss of balance; seizures; shuffling walk; uncontrolled movements of the arms or legs; yellowing of the skin or eyes.
For Healthcare Professionals
Applies to benzocaine / trimethobenzamide: rectal suppository
Cardiovascular side effects have included hypotension. It has been occasionally associated with intramuscular administration of trimethobenzamide in surgical patients.
Gastrointestinal side effects have included diarrhea.
Hematologic side effects have rarely included blood dyscrasias. Methemoglobinemia, characterized by cyanosis, has been reported with the use of benzocaine topical.
Hepatic side effects have included hepatotoxicity and jaundice associated with the use of trimethobenzamide.
An isolated case report described a 50-year-old white female receiving trimethobenzamide capsules during a study protocol for use as a prophylactic antiemetic. After two days of administration, the patient had become jaundiced and her urine was dark. She felt tired, anorexic and nauseated with mild epigastric pain. A liver scan four days after the episode indicated hepatocellular dysfunction. She denied any other factors which may have contributed to the episode.
Hypersensitivity side effects have included allergic-type skin reactions. Bronchospasm, shock, and anaphylactoid reactions may occur and, in general, have occurred with high plasma levels of the local anesthetic. Parkinson-like symptoms have been reported following the use of trimethobenzamide. These have abated following drug discontinuation, but in some cases treatment may be indicated.
Musculoskeletal side effects have included muscle cramps associated with the use of trimethobenzamide.
Extrapyramidal reactions to trimethobenzamide have been reported in some patients, the youngest of whom was 2 weeks old. This patient received approximately 300 mg rectally, although the drug is not recommended for newborn infants.
Nervous system side effects have included dizziness, drowsiness, headache, disorientation, convulsions, opisthotonus, Parkinson's-like symptoms, trismus, and extrapyramidal symptoms.
Psychiatric side effects have included depression.
Local side effects have included burning, stinging, tenderness, and sloughing following the use of benzocaine topical. Pain has been reported following the intramuscular administration of trimethobenzamide.
Ocular side effects have included blurred vision following the use of trimethobenzamide.
More about benzocaine/trimethobenzamide
- Other brands: Tebamide
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