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Atgam Side Effects

Generic name: lymphocyte immune globulin, anti-thy (equine)

Medically reviewed by Drugs.com. Last updated on Jan 17, 2024.

Note: This document contains side effect information about lymphocyte immune globulin, anti-thy (equine). Some dosage forms listed on this page may not apply to the brand name Atgam.

Applies to lymphocyte immune globulin, anti-thy (equine): parenteral concentrate for injection.

Warning

  • Should be used only by clinicians experienced in immunosuppressive therapy for the management of renal transplant or aplastic anemia patients.b

  • Patients receiving antithymocyte globulin (equine) should be treated in facilities equipped and staffed with adequate laboratory and supportive medical resources.b

Side effects include:

Renal allotransplantation: Fever, chills, leukopenia, thrombocytopenia, dermatologic reactions (rash, pruritus, urticaria, wheal and flare).

Aplastic anemia: Fever, chills, skin reactions, arthralgia, headache, myalgia, nausea, chest pain, phlebitis, serum sickness.

For Healthcare Professionals

Applies to lymphocyte immune globulin, anti-thy (equine): intravenous solution.

Hypersensitivity

Uncommon (0.1% to 1%): Anaphylactic reaction[Ref]

Dermatologic

Very common (10% or more): Rash (26%)

Common (1% to 10%): Urticaria, pruritus, vomiting, diarrhea, abdominal pain upper

Uncommon (0.1% to 1%): Herpes simplex, allergic dermatitis, toxic epidermal necrolysis (TEN)

Postmarketing reports: Hyperhidrosis[Ref]

Musculoskeletal

Very common (10% or more): Arthralgia (17%)

Common (1% to 10%): Chest pain, back pain[Ref]

Gastrointestinal

Common (1% to 10%): Nausea

Uncommon (0.1% to 1%): Stomatitis

Postmarketing reports: Abdominal pain, GI hemorrhage, GI perforation, oral pain[Ref]

Cardiovascular

Common (1% to 10%): Thrombophlebitis, hypertension, hypotension, bradycardia, arteriovenous fistula thrombosis, tachycardia, iliac vein occlusion

Postmarketing reports: Congestive heart failure, deep vein thrombosis, vasculitis[Ref]

Hematologic

Very common (10% or more): Thrombocytopenia (22%), leukopenia (18%)

Postmarketing reports: Anemia, eosinophilia, granulocytopenia, hemolysis, hemolytic anemia, neutropenia, pancytopenia[Ref]

Respiratory

Common (1% to 10%): Dyspnea

Uncommon (0.1% to 1%): Pleural effusion, hiccups, laryngospasm, pulmonary edema

Postmarketing reports: Apnea, cough, epistaxis, oropharyngeal pain[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness

Uncommon (0.1% to 1%): Convulsion, encephalitis, paresthesia

Postmarketing reports: Dyskinesia, Syncope, tremor[Ref]

Local

Common (1% to 10%): Infusion site pain

Postmarketing reports: Infusion site erythema, infusion site swelling[Ref]

Renal

Uncommon (0.1% to 1%): Renal function test abnormal, renal artery thrombosis

Postmarketing reports: Kidney rupture, renal failure acute[Ref]

Ocular

Uncommon (0.1% to 1%): Periorbital edema[Ref]

Metabolic

Uncommon (0.1% to 1%): Night sweats, hyperglycemia, proteinuria

Postmarketing reports: Flank pain, muscle rigidity, myalgia, pain in extremity[Ref]

Hepatic

Common (1% to 10%): Liver function test abnormal[Ref]

Immunologic

Common (1% to 10%): Infection

Uncommon (0.1% to 1%): Serum sickness

Postmarketing reports: Hepatitis viral, localized infection, systemic infection[Ref]

Psychiatric

Uncommon (0.1% to 1%): Agitation

Postmarketing reports: Confusion, disorientation[Ref]

Other

Very common (10% or more): Pyrexia (40%), chills (27%)

Common (1% to 10%): Edema, lymphadenopathy, asthenia, malaise, wound dehiscence

Postmarketing reports: Aplasia, pain[Ref]

References

1. Product Information. Atgam (lymphocyte immune globulin, anti-thy (equine)). Pfizer U.S. Pharmaceuticals Group. 2010.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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