Ancef Side Effects

Generic name: cefazolin

Medically reviewed by Drugs.com. Last updated on Mar 24, 2024.

Note: This document provides detailed information about Ancef Side Effects associated with cefazolin. Some dosage forms listed on this page may not apply specifically to the brand name Ancef.

Applies to cefazolin: injection powder for solution.

Serious side effects of Ancef

Along with its needed effects, cefazolin (the active ingredient contained in Ancef) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking cefazolin:

Rare

• bluish color
• changes in skin color
• pain
• swelling of the foot or leg
• tenderness

Incidence not known

• abdominal or stomach cramps or tenderness
• back, leg, or stomach pains
• black, tarry stools
• bleeding gums
• blistering, peeling, or loosening of the skin
• bloating
• blood in the urine or stools
• bloody or cloudy urine
• chest pain
• chills
• clay-colored stools
• cloudy urine
• cough
• coughing up blood
• dark urine
• decrease in urine output or decrease in urine-concentrating ability
• decreased frequency or amount of urine
• diarrhea
• diarrhea, watery and severe, which may also be bloody
• difficult or painful urination
• difficulty with breathing or swallowing
• dizziness
• excessive muscle tone
• fast heartbeat
• feeling of discomfort
• fever
• general body swelling
• general tiredness and weakness
• headache
• hives
• increased blood pressure
• increased menstrual flow or vaginal bleeding
• increased thirst
• inflammation of the joints
• itching
• itching of the vagina or genital area
• joint or muscle pain
• light-colored stools
• loss of appetite
• lower back or side pain
• muscle aches or stiffness
• muscle tension or tightness
• nausea or vomiting
• nosebleeds
• pain during sexual intercourse
• pain, warmth, or burning in the fingers, toes, and legs
• pale skin
• paralysis
• pinpoint red spots on the skin
• problems with vision or hearing
• prolonged bleeding from cuts
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• rash
• red irritated eyes
• red or black, tarry stools
• red or dark brown urine
• red skin lesions, often with a purple center
• red, irritated eyes
• restlessness
• seizures
• skin rash
• sore throat
• sores, ulcers, or white spots on the lips or in the mouth
• stomach cramps
• sudden decrease in the amount of urine
• swelling of the face, fingers, or lower legs
• swollen lymph glands
• swollen or painful glands
• thick, white vaginal discharge with no odor or with a mild odor
• tightness in the chest
• trouble sitting still
• troubled breathing
• unpleasant breath odor
• unusual bleeding or bruising
• unusual tiredness or weakness
• unusual weight loss
• upper right abdominal pain
• vomiting
• vomiting of blood
• weight gain
• wheezing
• yellowing of the eyes or skin

Other side effects of Ancef

Some side effects of cefazolin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
• hives or welts
• redness of the skin
• sore mouth or tongue
• weight loss
• white patches in the mouth, tongue, or throat

For Healthcare Professionals

Applies to cefazolin: injectable powder for injection, injectable solution, intravenous powder for injection, intravenous solution.

Gastrointestinal

• Common (1% to 10%): Diarrhea, vomiting, nausea
• Uncommon (0.1% to 1%): Oral candidiasis (oral thrush)
• Very rare (less than 0.01%): Anal pruritus, pseudomembranous colitis
• Frequency not reported: Mouth ulcers, abdominal/stomach cramps, epigastric pain, heartburn, flatus, Clostridium difficile-associated diarrhea, colitis
• Cephalosporin-class:
• Frequency not reported: Colitis, abdominal pain^[Ref]

Diarrhea, nausea, vomiting, and loss of appetite were usually of moderate severity and frequently resolved during or after therapy.

Oral candidiasis has been reported during prolonged therapy.

The onset of pseudomembranous colitis symptoms has been reported during or after antibacterial therapy.^[Ref]

Metabolic

• Common (1% to 10%): Loss of appetite
• Rare (0.01% to 0.1%): Increased blood glucose level/hyperglycemia, decreased blood glucose level/hypoglycemia
• Frequency not reported: Anorexia^[Ref]

Local

• Common (1% to 10%): Pain at IM injection site (sometimes with induration)
• Uncommon (0.1% to 1%): Thrombophlebitis with IV administration
• Frequency not reported: Phlebitis at injection site, induration^[Ref]

Dermatologic

Uncommon (0.1% to 1%): Erythema, erythema multiforme, exanthema, urticaria, angioedema (reversible local permeability of blood vessels, joints, mucous membranes)
Rare (0.01% to 0.1%): Toxic epidermal necrolysis (Lyell's syndrome), Stevens-Johnson syndrome
Frequency not reported: Pruritus, skin rash, fixed drug eruptions, pustular skin eruptions, contact dermatitis

Cephalosporin-class:
Frequency not reported: Urticaria, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis^[Ref]

A case of occupational contact dermatitis due to cephalosporin allergy has been reported in a nurse who prepared cephalosporin solutions for administration to patients. The dermatitis resolved after the nurse stopped preparing the solutions.^[Ref]

Nervous system

Uncommon (0.1% to 1%): Seizures
Rare (0.01% to 0.1%): Dizziness, vertigo, hyperactivity, drowsiness, epileptogenic activity
Frequency not reported: Fainting, lightheadedness, somnolence, headache, encephalopathy (symptoms included tonic-clonic seizures, lethargy, disorientation, memory loss, asterixis, multifocal myoclonus)

Cephalosporin-class:
Frequency not reported: Hyperactivity, hypertonia^[Ref]

Seizures have been reported when inappropriately high doses were administered to patients with renal dysfunction (CrCl less than 55 mL/min).

Encephalopathy has been reported in patients with renal failure. Toxicity was due to increased drug serum levels and increased permeability of blood-brain barrier caused by uremia.^[Ref]

Other

Uncommon (0.1% to 1%): Drug-induced fever
Rare (0.01% to 0.1%): Malaise, fatigue, weakness, hot flushes, chest pain, increased LDH, increased alkaline phosphatase
Very rare (less than 0.01%): Face edema
Frequency not reported: Tiredness

Cephalosporin-class:
Frequency not reported: Elevated LDH, superinfection, false-positive test for urinary glucose^[Ref]

Respiratory

• Uncommon (0.1% to 1%): Interstitial pneumonia/pneumonitis
• Rare (0.01% to 0.1%): Pleural effusion, dyspnea, respiratory distress, cough, rhinitis^[Ref]

Hematologic

• Rare (0.01% to 0.1%): Neutropenia, leukopenia, thrombocytopenia, granulocytopenia, leukocytosis, granulocytosis, monocytosis, lymphocytopenia, basophilia, eosinophilia
• Very rare (less than 0.01%): Coagulation (blood clotting) disorders, bleeding, decreased hemoglobin, decreased hematocrit, anemia, agranulocytosis, aplastic anemia, pancytopenia, hemolytic anemia
• Frequency not reported: Thrombocythemia, hematoma, increased thrombin time, increased prothrombin time, increased partial thromboplastin time, positive direct and indirect Coombs tests
• Cephalosporin-class:
• -Frequency not reported: Aplastic anemia, hemolytic anemia, hemorrhage, prolonged prothrombin time, pancytopenia, agranulocytosis^[Ref]

Rare (0.01% to 0.1%): Neutropenia, leukopenia, thrombocytopenia, granulocytopenia, leukocytosis, granulocytosis, monocytosis, lymphocytopenia, basophilia, eosinophilia
Very rare (less than 0.01%): Coagulation (blood clotting) disorders, bleeding, decreased hemoglobin, decreased hematocrit, anemia, agranulocytosis, aplastic anemia, pancytopenia, hemolytic anemia
Frequency not reported: Thrombocythemia, hematoma, increased thrombin time, increased prothrombin time, increased partial thromboplastin time, positive direct and indirect Coombs tests

Cephalosporin-class:
Frequency not reported: Aplastic anemia, hemolytic anemia, hemorrhage, prolonged prothrombin time, pancytopenia, agranulocytosis^[Ref]

Hepatic

• Rare (0.01% to 0.1%): Increased AST, increased ALT, increased GGT, increased bilirubin, hepatitis (transient), cholestatic jaundice (transient)
• Cephalosporin-class:
• Frequency not reported: Hepatic dysfunction (including cholestasis), elevated bilirubin^[Ref]

Transient increases in AST, ALT, GGT, bilirubin, LDH, and alkaline phosphatase have been reported.^[Ref]

Renal

• Rare (0.01% to 0.1%): Nephrotoxicity, interstitial nephritis, undefined nephropathy, increased BUN (transient)
• Frequency not reported: Increased creatinine levels, renal failure, increased serum urea
• Cephalosporin-class:
• -Frequency not reported: Renal dysfunction, toxic nephropathy, increased creatinine, interstitial nephritis (reversible fever, azotemia, pyuria, eosinophiluria; with some cephalosporins)^[Ref]

Rare (0.01% to 0.1%): Nephrotoxicity, interstitial nephritis, undefined nephropathy, increased BUN (transient)
Frequency not reported: Increased creatinine levels, renal failure, increased serum urea

Cephalosporin-class:
Frequency not reported: Renal dysfunction, toxic nephropathy, increased creatinine, interstitial nephritis (reversible fever, azotemia, pyuria, eosinophiluria; with some cephalosporins)^[Ref]

Genitourinary

• Rare (0.01% to 0.1%): Vaginitis, genital candidiasis (moniliasis), proteinuria
• Very rare (less than 0.01%): Genital pruritus
• Frequency not reported: Vulvar pruritus^[Ref]

Psychiatric

• Rare (0.01% to 0.1%): Nightmares, nervousness/anxiety, insomnia, confusion

Ocular

• Rare (0.01% to 0.1%): Disturbed color vision

Hypersensitivity

Very rare (less than 0.01%): Anaphylactic shock (including swelling of larynx with narrowing of airways, increased heart rate, shortness of breath, falling blood pressure, swollen tongue)
Frequency not reported: Anaphylaxis, allergic reaction (including eosinophilia, urticaria, itching, drug fever, skin rash, Stevens-Johnson syndrome), allergic cross-sensitivity

Cephalosporin-class:
Frequency not reported: Allergic reactions, serum sickness-like reaction^[Ref]

Cardiovascular

• Frequency not reported: Hypotension^[Ref]

Further information

Ancef side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer