Alrex Side Effects

Generic Name: loteprednol ophthalmic

Note: This page contains information about the side effects of loteprednol ophthalmic. Some of the dosage forms included on this document may not apply to the brand name Alrex.

Not all side effects for Alrex may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to loteprednol ophthalmic: ophthalmic gel/jelly, ophthalmic ointment, ophthalmic suspension

Along with its needed effects, loteprednol ophthalmic (the active ingredient contained in Alrex) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking loteprednol ophthalmic:

More common
  • Blurred vision or other change in vision
  • redness or swelling of the eye
  • sensitivity of the eyes to light
  • swelling of the membrane covering the white part of the eye
Less common
  • Discharge from the eye
  • eye discomfort, irritation, or pain
  • redness of the eyelid or inner lining of the eyelid
  • tiny bumps on the inner lining of the eyelid
Incidence not known
  • Blindness
  • delayed wound healing
  • loss of vision
  • nausea or vomiting

Some side effects of loteprednol ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Burning when medicine is applied
  • dry eyes
  • feeling of something in the eye
  • headache
  • itching
  • runny nose
  • sore throat
  • tearing or watery eye

For Healthcare Professionals

Applies to loteprednol ophthalmic: ophthalmic gel, ophthalmic ointment, ophthalmic suspension

Ocular

Very common (10% or more): Anterior chamber inflammation with ointment (25%), occurring in 5 to 15% of patients: Abnormal vision/blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, photophobia
Common (1% to 10%): Anterior chamber inflammation with gel (5%), conjunctival hyperemia, corneal edema, eye pain, foreign body sensation, occurring in less than 5% of patients: conjunctivitis, corneal abnormalities, eyelid erythema, keratoconjunctivitis, ocular irritation/discomfort, papillae, uveitis
Frequency not reported: Elevated intraocular pressure (may be associated with infrequent optic nerve damage), visual acuity and field defects, posterior subcapsular cataract formation, delayed wound healing, secondary ocular infection (including herpes simplex), perforation of the globe (where there is thinning of the cornea or sclera), keratitis, corneal ulcers, loss of accommodation, ptosis

Randomized studies involving patients treated with loteprednol etabonate therapy for 28 days or longer revealed the incidence of significant elevation in intraocular pressure (>= 10 mmHg) was 2% (15/901) with loteprednol etabonate, 7% (11/164) with 1% prednisolone acetate and 0.5% (3/583) with placebo.

Respiratory

Very common (10% or more): Occurring in less than 15% of patients: rhinitis, pharyngitis

Nervous system

Very common (10% or more): Headache

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