A-Spaz Side Effects
Generic Name: hyoscyamine
Note: This page contains information about the side effects of hyoscyamine. Some of the dosage forms included on this document may not apply to the brand name A-Spaz.
Not all side effects for A-Spaz may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
For the Consumer
Applies to hyoscyamine: oral capsule extended release, oral liquid, oral solution, oral spray, oral tablet, oral tablet chewable, oral tablet disintegrating, oral tablet extended release, sublingual tablet
Get emergency medical help if you have any of these signs of an allergic reaction while taking hyoscyamine (the active ingredient contained in A-Spaz) hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using hyoscyamine and call your doctor at once if you have any of these serious side effects:
unusual thoughts or behavior;
fast, pounding, or uneven heart rate;
rash or flushing (warmth, redness, or tingly feeling); or
Less serious side effects of hyoscyamine may include:
dizziness, drowsiness, feeling nervous;
blurred vision, headache;
sleep problems (insomnia);
nausea, vomiting, bloating, heartburn, or constipation;
changes in taste;
problems with urination;
dry mouth; or
impotence, loss of interest in sex, or trouble having an orgasm.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to hyoscyamine: compounding powder, injectable solution, oral capsule extended release, oral liquid, oral solution, oral spray, oral tablet, oral tablet chewable, oral tablet disintegrating, oral tablet extended release, sublingual tablet
Cardiovascular side effects have included tachycardia, premature ventricular depolarizations, and ventricular tachycardia.
Gastrointestinal side effects due to the anticholinergic effects of hyoscyamine (the active ingredient contained in A-Spaz) have commonly included dry mouth and mucous membranes. Other reported side effects include delayed gastric emptying time, reduced gastric acid secretion, constipation, and gastroesophageal reflux.
Hyoscyamine (the active ingredient contained in A-Spaz) toxicity (anticholinergic side effects) often presents as fever, tachycardia, agitation, and dry skin/mucous membranes.
Genitourinary complications include urinary retention (due to anticholinergic effects on the urinary sphincter), which is common and dose-related, and impotence in male patients.
Hypersensitivity reactions to hyoscyamine (the active ingredient contained in A-Spaz) are rare. Reactions can include urticaria, eczema, papillary hyperplasia, mucopurulent discharge, eosinophilia, pruritus, edema, hypotension, abdominal pain, tachypnea, nausea and vomiting.
Nervous system side effects have included lethargy and somnolence. Higher doses may be associated with mental confusion and/or excitement. The elderly appear to be more prone to the anticholinergic effects of hyoscyamine (the active ingredient contained in A-Spaz) on the CNS.
Ocular side effects due to the anticholinergic activity of hyoscyamine (the active ingredient contained in A-Spaz) have included inhibition of the iris sphincter muscle (possibly resulting in mydriasis), follicular conjunctivitis, and inhibition of the ciliary muscle (which can produce blurred vision). All muscarinic antagonists can precipitate glaucoma.
Endocrine side effects have included inhibition of exocrine sweat glands. This is usually not clinically significant except when perspiration becomes a major factor in body temperature control.
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