Hyoscyamine Dosage

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Irritable Bowel Syndrome

Immediate-release Tablets: 0.125 to 0.25 mg orally or sublingually every 4 hours or as needed. Do not take more than 12 tablets in 24 hours.

Extended-release Tablets: 0.375 to 0.75 mg orally every 12 hours. Do not exceed 4 tablets in 24 hours.

Timecaps: 0.375 to 0.75 mg orally every 12 hours. Do not exceed 4 capsules in 24 hours

Biphasic tablets: 0.375 to 0.75 mg orally every 12 hours. Dosage may be adjusted to 0.375 mg every 8 hours if needed. Do not exceed 4 tablets in 24 hours.

Elixir: 5 to 10 mL (0.125 to 0.25 mg) every 4 hours or as needed. Do not take more than 12 teaspoonfuls in 24 hours.

Drops: 1 to 2 mL (0.125 to 0.25 mg) every 4 hours as needed. Do not take more than 12 mL in 24 hours.

Usual Adult Dose for Anesthesia

5 mcg/kg administered 30 to 60 minutes prior to the time of induction of anesthesia or given at the time the preanesthetic narcotic or sedative are administered.

Usual Adult Dose for Endoscopy or Radiology Premedication

Parenteral:
0.25 to 0.5 mg (0.5 to 1 mL) IV 5 to 10 minutes prior to the diagnostic procedure.

Oral Spray:
Endoscopic retrograde cholangiopancreatography: 2 sprays (0.25 mg) 20 minutes prior to the procedure.

Usual Pediatric Dose for Urinary Incontinence

Greater than or equal to 2 to less than 12 years:
Immediate-release Tablets: 0.0625 to 0.125 mg sublingually, orally, chew, every 4 hours or as needed. Do not take more than 6 tablets in 24 hours.

Elixir: 1.25 to 5 mL (10 kg to 50 kg child) every 4 hours or as needed. Increase dose by 1.25 mL increments for a 20 kg child, and again for a 40 kg child. Do not take more than 6 teaspoonfuls in 24 hours.

Drops: 0.25 to 1 mL (0.0312 to 0.125 mg) every 4 hours as needed. Do not give more than 6 mL in 24 hours.

Biphasic tablets: 0.375 mg orally every 12 hours. Do not exceed 2 tablets in 24 hours.

Less than 2 years:
Drops: 4 drops for a 3.4 kg child (Do not give more than 24 drops in 24 hours)
5 drops for a 5 kg child (Do not give more than 30 drops in 24 hours),
6 drops for a 7 kg child (Do not give more than 36 drops in 24 hours),
8 drops for a 10 kg child (Do not give more than 48 drops in 24 hours)

Usual Pediatric Dose for Irritable Bowel Syndrome

Study (n=28)
Greater than 9 years: 0.375 mg orally at bedtime, up to 0.75 mg, for up to 6 months.

Usual Pediatric Dose for Anesthesia

5 mcg/kg administered 30 to 60 minutes prior to the time of induction of anesthesia or given at the time the preanesthetic narcotic or sedative are administered.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

As with other anticholinergic agents, hyoscyamine is contraindicated for patients with angle-closure glaucoma, and should be used cautiously in patients with pyloric or suspected intestinal obstruction or urinary bladder neck obstruction, and in patients with myasthenia gravis.

Use with caution in patients with hiatal hernia associated with reflux esophagitis.

Caution should be exercised when using hyoscyamine in patients with: autonomic neuropathy, hyperthyroidism, coronary heart disease, congestive heart failure, cardiac arrhythmias, hypertension and renal disease.

Hyoscyamine may cause drowsiness, confusion, and disorientation. The elderly and the renally or hepatically impaired may be particularly sensitive to these effects. All patients should be cautioned against engaging in activities which require mental alertness, such as driving or operating dangerous machinery, while using hyoscyamine. The concomitant use of alcohol or other agents possessing CNS depressant activity should be avoided if possible.

Anticholinergics may increase the heart rate, for this reason the occurrence of tachycardia should be closely evaluated before giving hyoscyamine.

Dialysis

Data not available

Other Comments

Extended release tablets, timecaps, and biphasic tablets should be swallowed whole. Do not crush or chew. The tablets are scored and may be broken to allow for easy dose titration.

Hyoscyamine sulfate injection may be administered subcutaneously, IM, or IV without dilution.

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