Home › Drugs A to Z › T › To › Topiramate Pregnancy Warnings
Print Save or Share

Topiramate Pregnancy and Breastfeeding Warnings

Topiramate is also known as: Topamax, Topamax Sprinkle, Topiragen

Overview

Topiramate Sprinkle Capsules may cause birth defects if you take it while you are pregnant. Avoid becoming pregnant by using an effective form of birth control while you are taking Topiramate Sprinkle Capsules. If you think you may be pregnant or you are planning to become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Topiramate Sprinkle Capsules while you are pregnant. Topiramate Sprinkle Capsules are found in breast milk. If you are or will be breast-feeding while you take Topiramate Sprinkle Capsules, check with your doctor. Discuss any possible risks to your baby.

Topiramate Pregnancy Warnings

Topiramate has been assigned to pregnancy category D by the FDA. Animal studies have revealed evidence of teratogenicity, embryotoxicity, and maternal toxicity. There are no controlled data in human pregnancy. Topiramate should only be given during pregnancy only when there are no alternatives and benefit outweighs risk.

Infants exposed to topiramate in utero have an increased risk for cleft lip and/or cleft palate (oral clefts). When multiple species of pregnant animals received topiramate at clinically relevant doses, structural malformations, including craniofacial defects, and reduced fetal weights occurred in offspring. The North American Antiepileptic Drug (NAAED) Pregnancy Registry is collecting information about the safety of antiepileptic drugs during pregnancy. All patients should be encouraged to enroll if they become pregnant. Patients can call the toll free number at 1-888-233-2334 or go to http://www.massgeneral.org/aed/.

Topiramate Breastfeeding Warnings

Topiramate has been demonstrated to be excreted into the milk of lactating rats.

There are no data on the excretion of topiramate into human milk.

See Also...

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This drug information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information in contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

(web4)