Tobramycin Pregnancy and Breastfeeding Warnings
Tobramycin is also known as: Bethkis, Nebcin, Nebcin Pediatric, TOBI Podhaler, Tobi
Tobramycin Pregnancy Warnings
Tobramycin has been assigned to pregnancy category D by the FDA. There are no controlled data in human pregnancies. Tobramycin crosses the placenta. While adverse fetal effects have not been noted after tobramycin use during pregnancy, there are reports of fetal eighth cranial nerve toxicity with permanent bilateral deafness after in utero exposure to other aminoglycosides. Tobramycin should only be given during pregnancy when benefit outweighs risk.
Tobramycin Breastfeeding Warnings
Parenteral: Tobramycin is excreted in human milk. Trace amounts have been measured in milk after intramuscular injection. Due to poor oral bioavailability, systemic toxicity in the nursing infant is unlikely; however, the possibility of bowel flora modification and interference with culture results should be considered. Inhalation: It is unknown whether nebulized tobramycin would reach sufficient serum concentrations to be excreted in human milk. Due to poor oral bioavailability, systemic toxicity in the nursing infant is unlikely; however, the manufacturer recommends that because of the potential for ototoxicity and nephrotoxicity in the nursing infant, a decision should be made whether to discontinue nursing or inhalation therapy.
See Also...
- Tobramycin use while Breastfeeding (in more detail)
- tobramycin Consumer Information
- Pregnancy Support Group
- FDA Pregnancy Categories
- Medicine use during Pregnancy
- Medicine use while Breastfeeding
- Safe Medications during Breastfeeding
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