Tobramycin Pregnancy and Breastfeeding Warnings
Tobramycin Pregnancy Warnings
Tobramycin has been assigned to pregnancy category D by the FDA. There are no controlled data in human pregnancies. Tobramycin crosses the placenta. While adverse fetal effects have not been noted after tobramycin use during pregnancy, there are reports of fetal eighth cranial nerve toxicity with permanent bilateral deafness after in utero exposure to other aminoglycosides. Tobramycin should only be given during pregnancy when benefit outweighs risk.
Tobramycin Breastfeeding Warnings
Parenteral: The manufacturer makes no recommendation regarding use during lactation. Inhalation: A decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother. Excreted into human milk: Yes Excreted into animal milk: Unknown Parenteral: Tobramycin has been used without apparent harmful effects in the nursing infant. Inhalation: The effects in the nursing infant are unknown.
Parenteral: Trace amounts of tobramycin have been measured in milk after intramuscular injection. Due to poor oral bioavailability, systemic toxicity in the nursing infant is unlikely; however, the possibility of bowel flora modification and interference with culture results should be considered. Inhalation: It is unknown whether nebulized tobramycin would reach sufficient serum concentrations to be excreted in human milk. Due to poor oral bioavailability, systemic toxicity in the nursing infant is unlikely; however, the manufacturer recommends that due to the potential for ototoxicity and nephrotoxicity in nursing infants, a decision should be made to discontinue nursing or discontinue the drug.
- Tobramycin use while Breastfeeding (in more detail)
- tobramycin Consumer Information
- Pregnancy Support Group
- FDA Pregnancy Categories
- Medicine use during Pregnancy
- Medicine use while Breastfeeding
- Safe Medications during Breastfeeding
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