Tobramycin Pregnancy and Breastfeeding Warnings
Tobramycin Pregnancy Warnings
Tobramycin has been assigned to pregnancy category D by the FDA. There are no controlled data in human pregnancies. Tobramycin crosses the placenta. While adverse fetal effects have not been noted after tobramycin use during pregnancy, there are reports of fetal eighth cranial nerve toxicity with permanent bilateral deafness after in utero exposure to other aminoglycosides. Tobramycin should only be given during pregnancy when benefit outweighs risk.
Tobramycin Breastfeeding Warnings
Parenteral: The manufacturer makes no recommendation regarding use during lactation. Inhalation: A decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother. Excreted into human milk: Yes Excreted into animal milk: Unknown Parenteral: Tobramycin has been used without apparent harmful effects in the nursing infant. Inhalation: The effects in the nursing infant are unknown.
Parenteral: Trace amounts of tobramycin have been measured in milk after intramuscular injection. Due to poor oral bioavailability, systemic toxicity in the nursing infant is unlikely; however, the possibility of bowel flora modification and interference with culture results should be considered. Inhalation: It is unknown whether nebulized tobramycin would reach sufficient serum concentrations to be excreted in human milk. Due to poor oral bioavailability, systemic toxicity in the nursing infant is unlikely; however, the manufacturer recommends that due to the potential for ototoxicity and nephrotoxicity in nursing infants, a decision should be made to discontinue nursing or discontinue the drug.
Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.com is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.