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Sulindac Pregnancy and Breastfeeding Warnings

Sulindac is also known as: Clinoril

Sulindac Pregnancy Warnings

Sulindac has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of developmental abnormalities. There are no controlled data in human pregnancy. While there are no reports linking the use of sulindac in pregnancy with birth defects, use late in pregnancy may cause premature closure of the ductus arteriosus and prolong labor and delivery. Sulindac should only be given during pregnancy when benefit outweighs risk. Sulindac should be avoided near term.

See references

Sulindac Breastfeeding Warnings

There are no data on the excretion of sulindac into human milk. The manufacturer recommends against nursing while the patient is receiving sulindac.

See references

References for pregnancy information

  1. Kramer WB, Saade G, Ou CN, Rognerud C, Dorman K, Mayes M, Moise KJ "Placental transfer of sulindac and its active sulfide metabolite in humans." Am J Obstet Gynecol 172 (1995): 886-90
  2. Ostensen M "Optimisation of antirheumatic drug treatment in pregnancy." Clin Pharmacokinet 27 (1994): 486-503

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