Sorafenib Pregnancy and Breastfeeding Warnings
Sorafenib is also known as: Nexavar
Sorafenib Pregnancy Warnings
Animal studies have revealed evidence of embryotoxicity, fetolethality, and teratogenicity. There are no controlled data in human pregnancy. The manufacturer states that based on the proposed mechanism of multikinase inhibition and multiple adverse effects seen in animals at exposure levels significantly below the clinical dose, sorafenib should be assumed to cause fetal harm when administered to a pregnant women.
FDA pregnancy category: D Use of sorafenib should be avoided. Instruct both men and women of childbearing potential to use effective birth control during treatment with sorafenib and for at least 2 weeks after stopping treatment.
Sorafenib Breastfeeding Warnings
Women should be advised against breast-feeding while receiving sorafenib. Excreted into human milk: Unknown Excreted into animal milk: Yes The effects in the nursing infant are unknown.
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