Sorafenib Pregnancy and Breastfeeding Warnings
Sorafenib is also known as: Nexavar
Sorafenib Pregnancy Warnings
Sorafenib has been assigned to pregnancy category D by the FDA. Animal studies have revealed evidence of embryotoxicity, fetolethality, and teratogenicity. There are no controlled data in human pregnancy. The manufacturer states that based on the proposed mechanism of multikinase inhibition and multiple adverse effects seen in animals at exposure levels significantly below the clinical dose, sorafenib should be assumed to cause fetal harm when administered to a pregnant women. Sorafenib should only be given during pregnancy when there are no alternatives and benefit outweighs risk.
Sorafenib Breastfeeding Warnings
There are no data on the excretion of sorafenib into human milk. Because many drugs are excreted into human milk and because the effects of sorafenib on infants have not been studied, the manufacturer has stated that women should be advised against breast-feeding while receiving sorafenib.
Animal studied have reported that the drug has been secreted into the milk of lactating animals.
- sorafenib Consumer Information
- Pregnancy Support Group
- FDA Pregnancy Categories
- Medicine use during Pregnancy
- Medicine use while Breastfeeding
- Safe Medications during Breastfeeding
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