Rifapentine Pregnancy and Breastfeeding Warnings

Rifapentine is also known as: Priftin

Rifapentine Pregnancy Warnings

In one clinical study, six patients randomized to rifapentine became pregnant during treatment. There were 2 normal deliveries, 2 first trimester spontaneous abortions, one elective abortion, and one lost to follow-up. Of the two patients with spontaneous abortions, one had a history of ethanol abuse and the other had HIV infection. When administered during the last few weeks of pregnancy, rifampin, a chemically related agent, has rarely been associated with maternal and neonatal hemorrhagic complications stemming from vitamin K deficiency. Prophylactic vitamin K is sometimes given, particularly if dietary vitamin K intake is inadequate. If rifapentine is used during the latter weeks of pregnancy, appropriate clotting parameters should be assessed in both patient and neonate.

Rifapentine has been assigned to pregnancy category C. Animal studies using doses similar to or less than the human dose (based on body surface area) have revealed evidence of teratogenicity. There are no controlled studies in human pregnancy. Rifapentine should only be given during pregnancy when benefit outweighs risk.

Rifapentine Breastfeeding Warnings

There are no data on the excretion of rifapentine into human milk. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

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