Piroxicam Pregnancy and Breast Feeding Warnings

Piroxicam is also known as: Feldene

Overview

Piroxicam may harm the fetus. Do not use it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Piroxicam while you are pregnant. Piroxicam is found in breast milk. Do not breast-feed while you are taking Piroxicam .

Piroxicam Pregnancy Warnings

Piroxicam has not been formally assigned to a pregnancy category by the FDA. Animal studies have failed to reveal evidence to embryotoxicity or teratogenicity. There are no controlled data in human pregnancy. Use late in pregnancy may result in premature closure of the ductus arteriosus and prolong labor and delivery. Piroxicam is only recommended for use during pregnancy when benefit outweighs risk. Piroxicam should be avoided near term.

Piroxicam Lactation Warnings

Piroxicam is excreted into human milk in small amounts. While the manufacturer recommends avoiding piroxicam during lactation, the American Academy of Pediatrics considers the drug to be compatible with breast-feeding.

In a study of four lactating women administered piroxicam 20 mg once a day for up to 52 days, milk to plasma ratios ranged from 0.01 to 0.03. The maximum concentration of piroxicam measured in milk was 141 mcg/mL, with a mean concentration of 78 mcg/mL. Neither piroxicam nor its conjugates were detected in the serum of one nursing infant. Similar results were obtained in an earlier report. Piroxicam milk concentrations ranged from 50 to 170 mcg/mL in one patient. Piroxicam was not detected in the serum of the nursing infant. Piroxicam milk concentrations ranged from 110 to 220 mcg/mL after a 40 mg dose in another patient.

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