Pentobarbital Pregnancy and Breastfeeding Warnings

Pentobarbital is also known as: Nembutal, Nembutal Sodium

Pentobarbital Pregnancy Warnings

Pentobarbital has been assigned to pregnancy category D by the FDA. An increased risk of congenital malformations has been associated with use of other barbiturates (including phenobarbital) and anticonvulsants during pregnancy. Pentobarbital has not been specifically implicated, but may pose similar risks. Defects associated with anticonvulsant use in pregnancy include neural tube defects, cleft lips, cleft palates, cardiac defects, and microcephaly. Neonatal barbiturate withdrawal symptoms have also been reported in infants whose mothers took barbiturates during pregnancy. There are no controlled data in human pregnancy. Pentobarbital should only be given during pregnancy when there are no alternatives and benefit outweighs risk.

Pentobarbital Breastfeeding Warnings

Pentobarbital is excreted into human milk in small amounts. The possibility of accumulation of other barbiturates in nursing infants has been reported, although pentobarbital has not been specifically implicated. The American Academy of Pediatrics has no formal position on pentobarbital but classifies phenobarbital as a drug which has "caused significant effects on some nursing infants and should be given to nursing mothers with caution."

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