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Naloxone / pentazocine Pregnancy and Breastfeeding Warnings

Naloxone / pentazocine is also known as: Talwin Nx

Naloxone / pentazocine Pregnancy Warnings

Naloxone-pentazocine has been assigned to pregnancy category C by the FDA. Naloxone animal data have failed to reveal evidence of impaired fertility or fetotoxicity after dosages equivalent to 50 times the recommended daily human dose. Administration during human pregnancy to a woman who is opioid-dependent may precipitate withdrawal in the woman and the fetus. Pentazocine animal studies have failed to reveal evidence of teratogenic or embryotoxic effects. There are no controlled data in human pregnancy for either drug. Naloxone-pentazocine should be given during pregnancy only when need has been clearly established.

Naloxone rapidly crosses the placenta. Fetal serum levels are lower than those of the mother.

Naloxone / pentazocine Breastfeeding Warnings

There are no data on the excretion of naloxone into human milk. Pentazocine is excreted into human milk. The manufacturer recommends that caution be used when administering naloxone-pentazocine to nursing women.

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