Milrinone Pregnancy and Breastfeeding Warnings
Milrinone Pregnancy Warnings
Milrinone has been assigned to pregnancy category C by the FDA. Animal studies failed to reveal evidence of teratogenicity at doses approximately 2.5 times the recommended human dosage. Studies have revealed increased resorption rates. There are no adequate or well-controlled studies during human pregnancy. Milrinone should only be given during pregnancy when benefit outweighs risk.
Placental transfer of milrinone was noted (baboon) when loading and continuous intravenous doses resulting in plasma concentrations considered therapeutic in human were administered. The maternal to fetal baboon serum ratio was approximately 4:1 during 3 hours of infusion.
Milrinone Breastfeeding Warnings
There are no data on the excretion of milrinone into human milk.
Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.com is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.