Lomefloxacin Pregnancy and Breastfeeding Warnings
Lomefloxacin is also known as: Maxaquin
Lomefloxacin Pregnancy Warnings
Of 549 cases reported by the European Network of Teratology Information Services involving exposure to other fluoroquinolones, congenital malformations were reported in 4.8%; however, this was not higher than the background rate.
Lomefloxacin has been assigned to pregnancy category C by the FDA. Some animal studies failed to reveal evidence of fetal harm; however, studies using high doses demonstrated fetotoxicity and teratogenicity. There are no controlled data in human pregnancies. Cartilage damage and arthropathies have been reported in immature animals giving rise to concern over effects on fetal bone formation. Because safer alternatives are available, some experts consider fluoroquinolones contraindicated during pregnancy, especially during the first trimester. The manufacturer recommends that lomefloxacin should only be given during pregnancy when benefit outweighs risk.
Lomefloxacin Breastfeeding Warnings
It is not known whether lomefloxacin is excreted in human milk. Other fluoroquinolones are excreted into human milk and lomefloxacin is excreted into rat milk. Quinolone-induced cartilage erosion and arthropathies that have been observed in juvenile animals render some concern over its possible toxic effects on the developing joints of nursing infants. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
- Lomefloxacin use while Breastfeeding (in more detail)
- lomefloxacin Consumer Information
- Pregnancy Support Group
- FDA Pregnancy Categories
- Medicine use during Pregnancy
- Medicine use while Breastfeeding
- Safe Medications during Breastfeeding
Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This drug information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information in contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.