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Latanoprost ophthalmic Pregnancy and Breastfeeding Warnings

Latanoprost ophthalmic is also known as: Xalatan

Latanoprost ophthalmic Pregnancy Warnings

Latanoprost ophthalmic solution has been assigned to pregnancy category C by the FDA. Animal data have revealed evidence of embryotoxicity at high doses. There are no controlled data in human pregnancy. Latanoprost should only be given during pregnancy when benefit outweighs risk.

One case report described the use of latanoprost and timolol gel-forming solution during an entire pregnancy. Placental insufficiency occurred, but the infant was normal. An observational study involving 10 pregnant women receiving latanoprost ophthalmic therapy during the first trimester of pregnancy, embryo exposure ranging from 4 to 70 days, reported a lack of maternal systemic side effects, threatening abortion or preterm labor, and neonatal malformation as a consequence of latanoprost. One patient experienced an early spontaneous abortion; however, latanoprost causality was deemed unlikely. Normal neonatal and maternal outcomes were reported in 3 women who continued therapy throughout pregnancy and 1 woman who discontinued therapy during the third trimester. Despite these reports the author cautions that considering the potential systemic oxytocic effects of all prostaglandin analogs latanoprost therapy during pregnancy is not yet advisable.

Latanoprost ophthalmic Breastfeeding Warnings

There are no data on the excretion of topically administered latanoprost or its metabolites into human milk. The manufacturer recommends that caution be used when administering latanoprost to nursing women.

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