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Inamrinone Pregnancy and Breastfeeding Warnings

Inamrinone is also known as: Inocor I V

Inamrinone Pregnancy Warnings

Limited animal data revealed skeletal and gross external malformations in rabbits after administration of inamrinone dosages approximately one to three times the maximum recommended human dosage (on a per kg basis). Other animal (rabbit and rat) studies failed to corroborate these findings. A single case in which an inamrinone dosage regimen of 0.5 mg per kg, then 2 mcg per kg per minute was administered to a pregnant woman (18 weeks) with bacterial endocarditis and heart failure has been reported. No adverse fetal effects were observed. However, due to her serious underlying disease, the woman spontaneously aborted 11 weeks after discontinuation of inamrinone.

Inamrinone has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of teratogenicity. There are no controlled data in human pregnancy. A case report of inamrinone use in a pregnant woman failed to reveal fetal toxicity, however, the pregnancy terminated in a spontaneous abortion several weeks following discontinuation of inamrinone. Inamrinone should be used during pregnancy only when benefit outweighs risk.

Inamrinone Breastfeeding Warnings

There are no data on the excretion of inamrinone into human milk. The manufacturer recommends that caution be used when administering inamrinone to nursing women.

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