Imipramine Pregnancy and Breast Feeding Warnings

Imipramine is also known as: Tofranil, Tofranil-PM

Overview

It is not known if Imipramine can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Imipramine while you are pregnant. It is not known if Imipramine is found in breast milk. Do not breast-feed while taking Imipramine .

Imipramine Pregnancy Warnings

Imipramine has not been formally assigned to a pregnancy category by the FDA. Several cases of congenital malformations, including limb reduction defects, in infants whose mothers took imipramine during pregnancy have been reported, although no firm association has been established. Neonatal withdrawal symptoms have also been reported. There are no controlled data in human pregnancy. Imipramine should only be given during pregnancy when there are no alternatives and benefit outweighs risk.

Imipramine Lactation Warnings

Imipramine and its active metabolite desipramine are excreted into human milk in small amounts. The American Academy of Pediatrics classifies imipramine as a drug "whose effect on nursing infants is unknown but may be of concern".

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