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Imipramine Pregnancy and Breastfeeding Warnings

Imipramine is also known as: Tofranil, Tofranil-PM

Imipramine Pregnancy Warnings

Imipramine has not been formally assigned to a pregnancy category by the FDA. Several cases of congenital malformations, including limb reduction defects, in infants whose mothers took imipramine during pregnancy have been reported, although no firm association has been established. Neonatal withdrawal symptoms have also been reported. There are no controlled data in human pregnancy. Imipramine should only be given during pregnancy when there are no alternatives and benefit outweighs risk.

Imipramine Breastfeeding Warnings

Imipramine and its active metabolite desipramine are excreted into human milk in small amounts. The American Academy of Pediatrics classifies imipramine as a drug "whose effect on nursing infants is unknown but may be of concern".

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